聚山梨酯 80 包裹白蛋白纳米粒递药系统治疗脑胶质瘤的研究
Polysorbate 80-coated albumin nanoparticles to deliver paclitaxel into the brain to treat glioma.
机构信息
Department of Pharmaceutics, College of Pharmaceutical Sciences, Dayananda Sagar University, Kumaraswamy Layout, Bangalore, Karnataka, 560078, India.
Department of Pharmacology, College of Pharmaceutical Sciences, Dayananda Sagar University, Kumaraswamy Layout, Bangalore, Karnataka, 560078, India.
出版信息
Ther Deliv. 2023 Mar;14(3):193-206. doi: 10.4155/tde-2022-0056. Epub 2023 Jun 9.
To develop stable paclitaxel (PTX)-loaded bovine serum albumin (BSA) nanoparticles (BSA-NPs-PTX) as drug-delivery vehicles for delivering paclitaxel into the brain to treat glioma. This study used PTX-loaded BSA NPs coated with polysorbate 80 (Ps 80) to enhance PTX concentration in the brain. The low IC indicated that the fabricated BSA-NPs-PTX and BSA-NPs-PTX-Ps 80 showed significantly enhanced cytotoxicity. The pharmacokinetic and biodistribution analysis of BSA-NPs-PTX and BSA-NPs-PTX 80 showed comparable pharmacokinetic profiles but were significantly different compared with free PTX. BSA-NPs-PTX-Ps 80 exhibited higher plasma concentration-time curves, as compared with BSA-NPs-PTX and PTX. BSA-NPs-PTX and BSA-NPs-PTX-Ps 80 showed significantly improved PTX distribution in the frontal cortex, posterior brain and cerebellum.
为了开发稳定的紫杉醇（PTX）负载牛血清白蛋白（BSA）纳米颗粒（BSA-NPs-PTX）作为药物递送载体，将紫杉醇递送至大脑以治疗神经胶质瘤。本研究使用聚山梨酯 80（Ps 80）包被的载紫杉醇 BSA NPs 来提高脑内紫杉醇浓度。低 IC 表明，所制备的 BSA-NPs-PTX 和 BSA-NPs-PTX-Ps 80 显示出显著增强的细胞毒性。BSA-NPs-PTX 和 BSA-NPs-PTX-Ps 80 的药代动力学和生物分布分析显示出可比的药代动力学特征，但与游离 PTX 有显著差异。与 BSA-NPs-PTX 和 PTX 相比，BSA-NPs-PTX-Ps 80 表现出更高的血浆浓度-时间曲线。BSA-NPs-PTX 和 BSA-NPs-PTX-Ps 80 显著提高了 PTX 在额叶皮质、后脑和小脑的分布。
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