表达解痉多肽化生在胃黏膜疾病中的作用。
Role of spasmolytic polypeptide-expressing metaplasia in gastric mucosal diseases.
作者信息
Liu Xi, Ma Zhiyuan, Deng Zilin, Yi Zhiqiang, Tuo Biguang, Li Taolang, Liu Xuemei
机构信息
Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University Zunyi, Guizhou, China.
Department of General Surgery, Affiliated Hospital of Zunyi Medical University Zunyi, Guizhou, China.
出版信息
Am J Cancer Res. 2023 May 15;13(5):1667-1681. eCollection 2023.
Abstract
Spasmolytic polypeptide-expressing metaplasia (SPEM) is a trefoil factor 2-expressing metaplasia in the fundic glands that resembles the fundic metaplasia of deep antral glandular cells and arises mainly from transdifferentiation of mature chief cells as well as mucous neck cells or isthmic stem cells. SPEM participates in the regulation of gastric mucosal injury, including focal and diffuse injury. This review focuses on the origin, models, and regulatory mechanisms of SPEM and on its role in the development of gastric mucosal injury. We hope to provide new prospects for the prevention and treatment of gastric mucosal diseases from the perspective of cell differentiation and transformation.
摘要
表达解痉多肽的化生（SPEM）是胃底腺中表达三叶因子2的化生，类似于胃窦深部腺细胞的胃底化生，主要由成熟主细胞以及黏液颈细胞或峡部干细胞转分化产生。SPEM参与胃黏膜损伤的调节，包括局灶性和弥漫性损伤。本综述重点关注SPEM的起源、模型和调节机制及其在胃黏膜损伤发展中的作用。我们希望从细胞分化和转化的角度为胃黏膜疾病的防治提供新的前景。
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