胃黏膜损伤的机制：聚焦于初始主细胞丢失这一关键靶点。
The mechanisms of gastric mucosal injury: focus on initial chief cell loss as a key target.
作者信息
Deng Zilin, Zhu Jiaxing, Ma Zhiyuan, Yi Zhiqiang, Tuo Biguang, Li Taolang, Liu Xuemei
机构信息
Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou Province, China.
Department of General Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou Province, China.
出版信息
Cell Death Discov. 2023 Jan 24;9(1):29. doi: 10.1038/s41420-023-01318-z.
Diffuse gastric mucosal injury is a chronic injury with altered cell differentiation, including spasmolytic polypeptide expression metaplasia (SPEM) and intestinal metaplasia (IM), which are considered precancerous lesions of gastric cancer (GC). Previously, most studies have focused on how parietal cell loss causes SPEM through transdifferentiation of chief cells. In theory, alteration or loss of chief cells seems to be a secondary phenomenon due to initial partial cell loss. However, whether initial chief cell loss causes SPEM needs to be further investigated. Currently, increasing evidence shows that initial chief cell loss is sufficient to induce gastric mucosal injury, including SPEM and IM, and ultimately lead to GC. Therefore, we summarized the two main types of models that explain the development of gastric mucosal injury due to initial chief cell loss. We hope to provide a novel perspective for the prevention and treatment of diffuse gastric mucosal injury.
弥漫性胃黏膜损伤是一种伴有细胞分化改变的慢性损伤，包括解痉多肽表达化生（SPEM）和肠化生（IM），它们被认为是胃癌（GC）的癌前病变。此前，大多数研究集中于壁细胞丢失如何通过主细胞转分化导致SPEM。理论上，主细胞的改变或丢失似乎是由于最初部分细胞丢失引起的继发现象。然而，最初的主细胞丢失是否会导致SPEM仍需进一步研究。目前，越来越多的证据表明，最初的主细胞丢失足以诱发胃黏膜损伤，包括SPEM和IM，并最终导致GC。因此，我们总结了两种主要模型，用以解释由于最初主细胞丢失导致胃黏膜损伤的发展过程。我们希望为弥漫性胃黏膜损伤的防治提供新的视角。
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