阿糖腺苷相关的脑病和肌阵挛。
Vidarabine-associated encephalopathy and myoclonus.
作者信息
Vilter R W
出版信息
Antimicrob Agents Chemother. 1986 May;29(5):933-5. doi: 10.1128/AAC.29.5.933.
Abstract
A 24-year-old man with disseminated herpes zoster, which occurred 9 months after bone marrow transplantation for chronic myeloid leukemia, developed encephalopathy and immobilizing myoclonus after 7 days of vidarabine treatment (10 mg/kg of body weight per day). Only mild hepatic dysfunction was a risk factor for a toxic reaction. After the vidarabine therapy was stopped, the symptoms worsened until treatment with hydration, large doses of chlordiazepoxide, and protective care gave symptomatic relief.
摘要
一名24岁男性，在接受慢性粒细胞白血病骨髓移植9个月后发生播散性带状疱疹，在接受阿糖腺苷治疗（每日10mg/kg体重）7天后出现脑病和固定性肌阵挛。仅有轻度肝功能不全是发生毒性反应的危险因素。停用阿糖腺苷治疗后，症状加重，直至通过补液、大剂量氯氮卓和保护性护理进行治疗后症状才有所缓解。
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3
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