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南非有和无宫内人类免疫缺陷病毒暴露的儿童中 T 细胞斑点试验的反应性。

T-SPOT.TB Reactivity in Southern African Children With and Without in Utero Human Immunodeficiency Virus Exposure.

机构信息

Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.

Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

出版信息

Clin Infect Dis. 2023 Oct 13;77(8):1133-1136. doi: 10.1093/cid/ciad356.

DOI:10.1093/cid/ciad356
PMID:37293702
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10573724/
Abstract

Infants who are human immunodeficiency virus (HIV)-exposed uninfected (iHEU) experience higher risk of infectious morbidity than infants HIV-unexposed uninfected (iHUU). We compared tuberculosis (TB) infection prevalence in 418 Bacillus Calmette-Guérin vaccinated sub-Saharan African iHEU and iHUU aged 9-18 months using T-SPOT.TB. Prevalence of TB infection was low and did not differ by HIV exposure status.

摘要

HIV 暴露未感染婴儿（iHEU）比 HIV 未暴露未感染婴儿（iHUU）有更高的传染性发病风险。我们使用 T-SPOT.TB 比较了 418 名接种卡介苗的撒哈拉以南非洲地区 9-18 月龄 iHEU 和 iHUU 中结核（TB）感染的流行率。TB 感染的流行率较低，且与 HIV 暴露状态无关。

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本文引用的文献

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Lower Insulin Sensitivity in Newborns With In Utero HIV and Antiretroviral Exposure Who Are Uninfected in Botswana.博茨瓦纳未感染 HIV 的宫内 HIV 暴露并接受抗逆转录病毒治疗新生儿胰岛素敏感性降低。
J Infect Dis. 2022 Nov 28;226(11):2002-2009. doi: 10.1093/infdis/jiac416.
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Non-IFNγ Whole Blood Cytokine Responses to Mycobacterium tuberculosis Antigens in HIV-exposed Infants.HIV 暴露婴儿对结核分枝杆菌抗原的非 IFNγ 全血细胞因子反应。
Pediatr Infect Dis J. 2021 Oct 1;40(10):922-929. doi: 10.1097/INF.0000000000003254.
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Breastfeeding mitigates the effects of maternal HIV on infant infectious morbidity in the Option B+ era.母乳喂养可减轻“B+方案”时代母婴 HIV 对婴儿传染性发病的影响。
AIDS. 2018 Oct 23;32(16):2383-2391. doi: 10.1097/QAD.0000000000001974.
4
High Incidence of Tuberculosis Infection in HIV-exposed Children Exiting an Isoniazid Preventive Therapy Trial.HIV 暴露儿童在结束异烟肼预防治疗试验后结核病感染率高。
Pediatr Infect Dis J. 2018 Oct;37(10):e254-e256. doi: 10.1097/INF.0000000000001946.
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Altered Natural Killer Cell Function in HIV-Exposed Uninfected Infants.暴露于HIV但未感染婴儿的自然杀伤细胞功能改变
Front Immunol. 2017 Apr 24;8:470. doi: 10.3389/fimmu.2017.00470. eCollection 2017.
6
Mortality in children diagnosed with tuberculosis: a systematic review and meta-analysis.儿童结核病诊断后的死亡率：一项系统评价与荟萃分析
Lancet Infect Dis. 2017 Mar;17(3):285-295. doi: 10.1016/S1473-3099(16)30474-1. Epub 2016 Dec 8.
7
HIV-exposed, uninfected infants: new global challenges in the era of paediatric HIV elimination.HIV 暴露但未感染的婴儿：儿科艾滋病消除时代的新全球挑战。
Lancet Infect Dis. 2016 Jun;16(6):e92-e107. doi: 10.1016/S1473-3099(16)00055-4. Epub 2016 Mar 31.
8
Tuberculosis Infection in Early Childhood and the Association with HIV-exposure in HIV-uninfected Children in Rural Uganda.乌干达农村未感染艾滋病毒儿童的儿童期结核感染及其与艾滋病毒暴露的关联
Pediatr Infect Dis J. 2016 May;35(5):524-9. doi: 10.1097/INF.0000000000001062.
9
In-utero exposure to maternal HIV infection alters T-cell immune responses to vaccination in HIV-uninfected infants.子宫内暴露于母体HIV感染会改变未感染HIV婴儿对疫苗接种的T细胞免疫反应。
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