Chen Xuling, Li Pengfei
Department of Chemistry, Guangdong Provincial Key Laboratory of Catalysis, Guangming Advanced Research Institute, College of Science, Southern University of Science and Technology, 1088 Xueyuan Blvd., Nanshan District, Shenzhen, Guangdong, 518055, China.
Chem Rec. 2023 Nov;23(11):e202300152. doi: 10.1002/tcr.202300152. Epub 2023 Jun 9.
Benefited from the rapid development of MBH reaction, the reaction of MBH adducts have been established as the most synthetically useful transformations. However, compared with the well-established allylic alkylations and (3+2)-annulations, the (1+4)-annulations of MBH adducts have not developed rapidly until recently. As a helpful complement to the (3+2)-annulations of MBH adducts, the (1+4)-annulations of MBH adducts opens a robust access to structurally diverse five-membered carbo- and heterocycles. This paper summarizes recent advances in organocatalytic (1+4)-annulations using MBH adducts as 1 C-synthons for the construction of functionalized five-membered carbo- and heterocycles.
受益于MBH反应的快速发展，MBH加合物的反应已成为最具合成实用性的转化反应。然而，与成熟的烯丙基烷基化反应和(3+2)环化反应相比，MBH加合物的(1+4)环化反应直到最近才得到迅速发展。作为MBH加合物(3+2)环化反应的有益补充，MBH加合物的(1+4)环化反应为构建结构多样的五元碳环和杂环提供了一条强有力的途径。本文总结了以MBH加合物作为1C合成子用于构建功能化五元碳环和杂环的有机催化(1+4)环化反应的最新进展。
