Ichihashi H
Gan To Kagaku Ryoho. 1986 Apr;13(4 Pt 2):1156-62.
In vitro drug testing using (3H) incorporation was utilized for specimens from 60 patients with advanced malignancies, mainly gastrointestinal cancers. Forty-six specimens had sufficient growth for drug testing. Forty-seven percent of stomach cancer specimens and 67% of colorectal cancer specimens demonstrated in vitro chemosensitivity. Among 9 chemotherapeutic agents tested, ara-C, 5-fluorouracil, and mitomycin C had higher percentages of positive sensitivity for stomach cancer, whereas actinomycin D, carboquone, and ACNU had a more pronounced effect on colorectal cancer. A comparison was made between the results of chemosensitivity tests and clinical response. In 46 drug assays, in vitro/in vivo drug responses were correlated in 78% with a true-positive predictive rate of 47% and a true-negative rate of 94%. This test appears to be a reliable indicator for clinical response to the same chemotherapeutic agents in human malignant disease.
利用（3H）掺入法对60例晚期恶性肿瘤患者（主要为胃肠道癌）的标本进行体外药物测试。46份标本有足够的生长量用于药物测试。47%的胃癌标本和67%的结直肠癌标本显示出体外化学敏感性。在所测试的9种化疗药物中，阿糖胞苷、5-氟尿嘧啶和丝裂霉素C对胃癌的阳性敏感性百分比更高，而放线菌素D、卡波醌和阿柔比星对结直肠癌的作用更明显。对化学敏感性测试结果与临床反应进行了比较。在46次药物检测中，体外/体内药物反应的相关性为78%，真阳性预测率为47%，真阴性率为94%。该测试似乎是人类恶性疾病中对相同化疗药物临床反应的可靠指标。
