Kato H, Aizawa K, Nishimiya K, Okitsu H, Konaka C, Kawate N, Yoneyama K, Shinohara H, Kinoshita K, Noguchi M
Gan To Kagaku Ryoho. 1986 Apr;13(4 Pt 2):1647-52.
Hematoporphyrin derivative has an affinity for malignant tissue and emits a red fluorescence when exposed to excitatory light. Therefore it is theoretically possible to make a diagnosis of cancer localization by observation of this fluorescence. The authors have been developing a new imaging system for cancer diagnosis using an excimer-dye laser. The excimer pulse has a 308 nm ultraviolet beam emitted by XeCl. Simplification and accuracy of the fluorescence diagnostic procedure was achieved by utilizing the nature of the pulse and a polychrometer. The diagnostic system permits endoscopic examination under ordinary observation light. Investigations have been performed in animal tumor models including FM-mouse (breast cancer) and beagle dog (esophageal cancer). Tumor tissue showed a distinct fluorescence, but no fluorescence could be observed in normal tissue, 72 hours after hematoporphyrin derivative administration.
血卟啉衍生物对恶性组织具有亲和力，在受到激发光照射时会发出红色荧光。因此，从理论上讲，通过观察这种荧光来诊断癌症的定位是可行的。作者一直在开发一种使用准分子染料激光的新型癌症诊断成像系统。准分子脉冲具有由XeCl发射的308nm紫外光束。通过利用脉冲的特性和多色仪实现了荧光诊断程序的简化和准确性。该诊断系统允许在普通观察光下进行内窥镜检查。已经在包括FM小鼠（乳腺癌）和比格犬（食管癌）在内的动物肿瘤模型中进行了研究。在给予血卟啉衍生物72小时后，肿瘤组织显示出明显的荧光，但在正常组织中未观察到荧光。
