Molaei Pejman, Savari Marzieh, Mahdavinezhad Ali, Najafi Rezvan, Afshar Saeid, Esfandiari Negin, Khorrami Ramin, Hashemi Mehrdad
Department of Molecular Medicine and Genetics, Research Center for Molecular Medicine, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Food Hygiene and Quality Control, Division of Epidemiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Pathol Res Pract. 2023 Aug;248:154592. doi: 10.1016/j.prp.2023.154592. Epub 2023 Jun 5.
Colorectal cancer (CRC) is known as one of the global problems that endangers the lives of thousands of people every year. Various treatments have been used to deal with this disease, but in some cases, they are not effective. Circular RNAs, as a novel class of noncoding RNAs, have different expression levels and various functions in cancer cells, such as gene regulation through microRNA sponging. They play an important role in various cellular processes, including differentiation, proliferation, invasion, and apoptosis. Changes in the process of apoptosis are closely related to the progression or inhibition of various malignancies. Induction of apoptosis in cancer cells is a promising target for tumor therapy. In this study, circRNAs were investigated as being central to the induction or inhibition of apoptosis in CRC. It is hoped that through targeted changes in the function of these biomolecules, better outcomes will be achieved in cancer treatment. Perhaps better outcomes for cancer treatment can be achieved by using new methods and modifying the expression of these nucleic acids. However, using this method may come with challenges and limitations.
结直肠癌（CRC）是一个全球性问题，每年危及成千上万人的生命。人们已采用各种治疗方法来应对这种疾病，但在某些情况下，这些方法并不有效。环状RNA作为一类新型非编码RNA，在癌细胞中具有不同的表达水平和多种功能，比如通过充当微小RNA海绵来进行基因调控。它们在包括分化、增殖、侵袭和凋亡在内的各种细胞过程中发挥着重要作用。凋亡过程中的变化与各种恶性肿瘤的进展或抑制密切相关。诱导癌细胞凋亡是肿瘤治疗的一个有前景的靶点。在本研究中，环状RNA被研究作为结直肠癌中诱导或抑制凋亡的核心因素。希望通过针对性改变这些生物分子的功能，在癌症治疗中取得更好的效果。或许通过使用新方法和改变这些核酸的表达，可以在癌症治疗中取得更好的效果。然而，使用这种方法可能会带来挑战和限制。
