Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, China; Department of Cardiology, Air Force Hospital of Western Theater Command, Chengdu, China.
Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, China.
J Am Med Dir Assoc. 2023 Nov;24(11):1783-1790.e2. doi: 10.1016/j.jamda.2023.04.025. Epub 2023 Jun 7.
To investigate the effect of moderate-intensity continuous training (MICT) on the improvement of cardiopulmonary function for patients undergoing transcatheter aortic valve replacement (TAVR).
Randomized controlled study.
Between August 20, 2021, and February 28, 2022, a total of 66 patients after TAVR were screened for inclusion and randomly divided into the MICT and control groups at a ratio of 1:1. MICT was scheduled 3 times per week for 3 months in the intervention group. Patients in the control group received one-time advice on physical activity according to the current guideline.
The primary endpoint was the 3-month change in peak oxygen consumption (peak VO) assessed by cardiopulmonary exercise testing. The secondary endpoints included the 3-month change in 6-minute walk test (6MWT), the 12-Item Short Form Health Survey (SF-12), New York Heart Association (NYHA) class, echocardiographic parameters, and laboratory parameters.
After 3 months, the change in peak VO was higher in the MICT group than that in the control group (1.63 mL/kg/min, 95% CI 0.58-2.67, P = .003). Change in 6MWT (21.55 m, 95% CI 0.38-42.71, P = .046) was higher in the MICT group compared with the control group. A significant change in favor of MICT was also observed for low-density lipoprotein cholesterol (-0.62 mmol/L, 95% CI -1.00 to -0.23, P = .002). However, there were no significant changes in other echocardiographic indices, laboratory parameters, and SF-12 between the 2 groups (all P > .05).
MICT had a positive effect on the cardiopulmonary function and physical capacity of patients after TAVR.
研究中等强度连续训练（MICT）对经导管主动脉瓣置换术（TAVR）后患者心肺功能改善的影响。
随机对照研究。
2021 年 8 月 20 日至 2022 年 2 月 28 日，共筛选出 66 例 TAVR 后患者纳入研究，并按照 1:1 的比例随机分为 MICT 组和对照组。干预组每周进行 3 次 MICT，持续 3 个月。对照组患者根据现行指南接受一次性体力活动建议。
主要终点为心肺运动试验评估的 3 个月时峰值摄氧量（peak VO）的变化。次要终点包括 3 个月时 6 分钟步行试验（6MWT）、12 项简明健康调查量表（SF-12）、纽约心脏协会（NYHA）心功能分级、超声心动图参数和实验室参数的变化。
3 个月后，MICT 组的 peak VO 变化高于对照组（1.63 mL/kg/min，95%CI 0.58-2.67，P =.003）。与对照组相比，MICT 组 6MWT 的变化更大（21.55 m，95%CI 0.38-42.71，P =.046）。MICT 组还观察到低密度脂蛋白胆固醇（-0.62 mmol/L，95%CI -1.00 至-0.23，P =.002）的显著改善。然而，两组间其他超声心动图指标、实验室参数和 SF-12 均无显著变化（均 P >.05）。
MICT 对 TAVR 后患者心肺功能和身体能力有积极影响。
