Correa Maria Elvira Pizzigati, Granzotto Fabiana Caramori Noal, Innocentini Lara Maria Alencar Ramos, Reis Thiago de Carvalho, de Lima Emilze Mafra, Varanda Renata de Freitas, Santos Paulo Sérgio da Silva, Junior Luiz Alberto Valente Soares, Bezinelli Leticia Mello, Eduardo Fernanda de Paula, Melo Walmyr Ribeiro, Antunes Héliton Spíndola, De Macedo Leandro Dorigan
Dental Ambulatory, Hematology and Blood Transfusion Center, University of Campinas, Brazil.
Serviço de Odontologia Hospitalar do Hospital Regina, Novo Hamburgo, Rio Grande do Sul, Brazil.
Hematol Transfus Cell Ther. 2023 Jul-Sep;45(3):358-367. doi: 10.1016/j.htct.2023.04.001. Epub 2023 May 30.
The oral involvement in the Hematopoietic Stem Cell Transplantation is well described in the literature. The goal of the dental treatment and management of the oral lesions related to the HSCT is to reduce the harm caused by preexisting oral infection or even the worsening of oral acute/chronic GVHD and late effects. The aim of this guideline was to discuss the dental management of patients subjected to HSCT, considering three phases of the HSCT: pre-HSCT, acute phase, and late phase. The literature published from 2010 to 2020 was reviewed in order to identify dental interventions in this patient population. The selected papers were divided into three groups: pre-HSCT, acute and late, and were reviewed by the SBTMO Dental Committee's members. When necessary, an expertise opinion was considered for better translating the guideline recommendations to our population dental characteristics. This manuscript focused on the pre-HSCT dental management. The objective of the pre-HSCT dental management is to identify possible dental situations that can worsening during the acute phase after the HSCT. Each guideline recommendations were made considering the Dentistry Specialties. The clinical consensus on dental management prior to HSCT provides professional health caregivers with clinical setting-specific information to help with the management of dental problems in patients to be subjected to HSCT.
造血干细胞移植中的口腔问题在文献中有详尽描述。与造血干细胞移植相关的口腔病变的牙科治疗及管理目标是减少既往口腔感染造成的损害，甚至降低口腔急性/慢性移植物抗宿主病及晚期效应的恶化程度。本指南旨在探讨接受造血干细胞移植患者的牙科管理，涵盖造血干细胞移植的三个阶段：造血干细胞移植前、急性期和晚期。回顾了2010年至2020年发表的文献，以确定该患者群体的牙科干预措施。所选论文分为三组：造血干细胞移植前、急性期和晚期，并由SBTMO牙科委员会成员进行审查。必要时，会参考专家意见，以便更好地将指南建议转化为适合我国人群的牙科特点。本手稿聚焦于造血干细胞移植前的牙科管理。造血干细胞移植前牙科管理的目标是识别可能在造血干细胞移植后急性期恶化的牙科情况。每项指南建议均根据牙科专业制定。造血干细胞移植前牙科管理的临床共识为专业医护人员提供了特定临床环境下的信息，以帮助管理即将接受造血干细胞移植患者的牙科问题。
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