X 染色体增强 NK 细胞反应。
X chromosome enhances NK cell responses.
机构信息
Dept. of Microbiology and Immunology, University of California - San Francisco, San Francisco, CA, USA; Parker Institute for Cancer Immunotherapy, University of California - San Francisco, San Francisco, CA, USA.
出版信息
Trends Genet. 2023 Aug;39(8):596-597. doi: 10.1016/j.tig.2023.05.003. Epub 2023 Jun 8.
Incomplete X-chromosome inactivation (XCI) can cause differences between sexes. Cheng et al. identified that the histone demethylase UTX, encoded by an X chromosome gene that escapes XCI, contributes to sex differences in natural killer (NK) cells, whereby males have increased NK cell numbers while female NK cells have enhanced responsiveness.
不完全的 X 染色体失活（XCI）可能导致性别差异。Cheng 等人发现，逃脱 XCI 的 X 染色体基因编码的组蛋白去甲基酶 UTX 有助于自然杀伤（NK）细胞的性别差异，男性 NK 细胞数量增加，而女性 NK 细胞的反应性增强。
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