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多组学遗传评分促进疾病研究。

Multi-omic genetic scores advance disease research.

机构信息

Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA; Department of Biostatistics and Health Data Science, School of Medicine, Indiana University, Indianapolis, IN, USA.

Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA; Department of Biostatistics and Health Data Science, School of Medicine, Indiana University, Indianapolis, IN, USA; Department of Translational Medical Sciences, College of Medicine, Texas A&M University, Houston, TX, USA; Brown Center for Immunotherapy, School of Medicine, Indiana University, Indianapolis, IN, USA.

出版信息

Trends Genet. 2023 Aug;39(8):600-601. doi: 10.1016/j.tig.2023.05.002. Epub 2023 Jun 7.

DOI:10.1016/j.tig.2023.05.002
PMID:37295977
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10526975/
Abstract

Multi-omic analysis is an effective approach for dissecting the mechanisms of diseases; however, collecting multi-omic data in large populations is time-consuming and costly. Recently, Xu et al. developed genetic scores for multi-omic traits and demonstrated their utilization to gain novel insights, advancing the application of multi-omic data in disease research.

摘要

多组学分析是剖析疾病机制的有效方法;然而,在大人群中收集多组学数据既耗时又昂贵。最近,Xu 等人开发了多组学特征的遗传评分,并展示了它们在获得新见解方面的应用,推动了多组学数据在疾病研究中的应用。

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Multi-omic genetic scores advance disease research.多组学遗传评分促进疾病研究。
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2
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Front Bioinform. 2024 Dec 16;4:1510352. doi: 10.3389/fbinf.2024.1510352. eCollection 2024.
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Genomic hallmarks and therapeutic targets of ribosome biogenesis in cancer.癌症中核糖体生物发生的基因组特征和治疗靶点。
Brief Bioinform. 2024 Jan 22;25(2). doi: 10.1093/bib/bbae023.
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PancanQTLv2.0: a comprehensive resource for expression quantitative trait loci across human cancers.PancanQTLv2.0:一个全面的人类癌症表达数量性状基因座资源。

本文引用的文献

1
An atlas of genetic scores to predict multi-omic traits.遗传评分图谱预测多组学特征
Nature. 2023 Apr;616(7955):123-131. doi: 10.1038/s41586-023-05844-9. Epub 2023 Mar 29.
2
Advancing CAR T cell therapy through the use of multidimensional omics data.通过使用多维组学数据来推进 CAR T 细胞疗法。
Nat Rev Clin Oncol. 2023 Apr;20(4):211-228. doi: 10.1038/s41571-023-00729-2. Epub 2023 Jan 31.
3
Addressing the challenges of polygenic scores in human genetic research.解决人类遗传研究中多基因评分面临的挑战。
Nucleic Acids Res. 2024 Jan 5;52(D1):D1400-D1406. doi: 10.1093/nar/gkad916.
Am J Hum Genet. 2022 Dec 1;109(12):2095-2100. doi: 10.1016/j.ajhg.2022.10.012.
4
Insights from multi-omics integration in complex disease primary tissues.复杂疾病原发性组织中多组学整合的研究进展。
Trends Genet. 2023 Jan;39(1):46-58. doi: 10.1016/j.tig.2022.08.005. Epub 2022 Sep 19.
5
Large-scale integration of the plasma proteome with genetics and disease.血浆蛋白质组与遗传学和疾病的大规模整合。
Nat Genet. 2021 Dec;53(12):1712-1721. doi: 10.1038/s41588-021-00978-w. Epub 2021 Dec 2.
6
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression.大规模顺式和反式 eQTL 分析确定了数千个调节血液基因表达的遗传位点和多基因评分。
Nat Genet. 2021 Sep;53(9):1300-1310. doi: 10.1038/s41588-021-00913-z. Epub 2021 Sep 2.
7
Statistical genetics and polygenic risk score for precision medicine.精准医学的统计遗传学与多基因风险评分
Inflamm Regen. 2021 Jun 17;41(1):18. doi: 10.1186/s41232-021-00172-9.
8
Opportunities and challenges for transcriptome-wide association studies.全转录组关联研究的机遇与挑战。
Nat Genet. 2019 Apr;51(4):592-599. doi: 10.1038/s41588-019-0385-z. Epub 2019 Mar 29.
9
The personal and clinical utility of polygenic risk scores.多基因风险评分的个体和临床效用。
Nat Rev Genet. 2018 Sep;19(9):581-590. doi: 10.1038/s41576-018-0018-x.
10
Multi-omics approaches to disease.疾病的多组学方法
Genome Biol. 2017 May 5;18(1):83. doi: 10.1186/s13059-017-1215-1.