对用于临床应用的人类诱导多能干细胞的基因组不稳定性进行合理考量。 - Suppr

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超能文献

A rational consideration of the genomic instability of human-induced pluripotent stem cells for clinical applications.

作者信息

Zhang Hang, Jin Zi-Bing

机构信息

Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.

出版信息

Sci China Life Sci. 2023 Sep;66(9):2198-2200. doi: 10.1007/s11427-023-2354-6. Epub 2023 Jun 2.

DOI:10.1007/s11427-023-2354-6

PMID:37296348

Abstract

摘要

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引用本文的文献

Patient-derived induced pluripotent stem cells with a mutation exhibit cell junction abnormalities and aberrant cellular differentiation potential.携带突变的患者来源的诱导多能干细胞表现出细胞连接异常和异常的细胞分化潜能。

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Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming.通过化学重编程高效快速生成人类多能干细胞。

Cell Stem Cell. 2023 Apr 6;30(4):450-459.e9. doi: 10.1016/j.stem.2023.02.008. Epub 2023 Mar 20.

Substantial somatic genomic variation and selection for BCOR mutations in human induced pluripotent stem cells.人诱导多能干细胞中大量的体细胞基因组变异和 BCOR 突变的选择。

Nat Genet. 2022 Sep;54(9):1406-1416. doi: 10.1038/s41588-022-01147-3. Epub 2022 Aug 11.

The Impact of Acquired Genetic Abnormalities on the Clinical Translation of Human Pluripotent Stem Cells.获得性遗传异常对人类多能干细胞临床转化的影响。

Cells. 2021 Nov 19;10(11):3246. doi: 10.3390/cells10113246.

Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions.不同培养条件下临床级人多能干细胞中低突变率。

Nat Commun. 2020 Mar 23;11(1):1528. doi: 10.1038/s41467-020-15271-3.

Research and therapy with induced pluripotent stem cells (iPSCs): social, legal, and ethical considerations.诱导多能干细胞（iPSCs）的研究和治疗：社会、法律和伦理方面的考虑。

Stem Cell Res Ther. 2019 Nov 21;10(1):341. doi: 10.1186/s13287-019-1455-y.

Stemming retinal regeneration with pluripotent stem cells.利用多能干细胞实现视网膜再生。

Prog Retin Eye Res. 2019 Mar;69:38-56. doi: 10.1016/j.preteyeres.2018.11.003. Epub 2018 Nov 9.

Feeders facilitate telomere maintenance and chromosomal stability of embryonic stem cells.饲养层有利于胚胎干细胞端粒的维持和染色体的稳定性。

Nat Commun. 2018 Jul 5;9(1):2620. doi: 10.1038/s41467-018-05038-2.

Humanized Mice Reveal Differential Immunogenicity of Cells Derived from Autologous Induced Pluripotent Stem Cells.人源化小鼠揭示了源自自体诱导多能干细胞的细胞的不同免疫原性。

Cell Stem Cell. 2015 Sep 3;17(3):353-9. doi: 10.1016/j.stem.2015.07.021. Epub 2015 Aug 20.

Concise review: Genomic stability of human induced pluripotent stem cells.简明综述：人类诱导多能干细胞的基因组稳定性。

Stem Cells. 2012 Jan;30(1):22-7. doi: 10.1002/stem.705.

Recurrent copy number variations in human induced pluripotent stem cells.人诱导多能干细胞中的复发性拷贝数变异

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