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A rational consideration of the genomic instability of human-induced pluripotent stem cells for clinical applications.

作者信息

Zhang Hang, Jin Zi-Bing

机构信息

Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.

出版信息

Sci China Life Sci. 2023 Sep;66(9):2198-2200. doi: 10.1007/s11427-023-2354-6. Epub 2023 Jun 2.

DOI:10.1007/s11427-023-2354-6

PMID:37296348

Abstract

摘要

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Substantial somatic genomic variation and selection for BCOR mutations in human induced pluripotent stem cells.

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The Impact of Acquired Genetic Abnormalities on the Clinical Translation of Human Pluripotent Stem Cells.

Cells. 2021 Nov 19;10(11):3246. doi: 10.3390/cells10113246.

Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions.

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Research and therapy with induced pluripotent stem cells (iPSCs): social, legal, and ethical considerations.

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Feeders facilitate telomere maintenance and chromosomal stability of embryonic stem cells.

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