Cowzer Darren, Keane Fergus, Ku Geoffrey Y
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Department of Medicine, Weill Cornell University, New York, NY 10065, USA.
Diagnostics (Basel). 2023 May 28;13(11):1884. doi: 10.3390/diagnostics13111884.
Esophageal adenocarcinoma, including adenocarcinoma of the gastroesophageal junction, is uncommon in the United States, but is associated with a rising incidence in young adults, and has a traditionally poor prognosis. Despite the incremental benefits that have been made with multimodality approaches to locally advanced disease, most patients will go on to develop metastatic disease, and long-term outcomes remain suboptimal. Over the last decade, PET-CT has emerged as a key tool in the management of this disease, with several prospective and retrospective studies evaluating its role in this disease. Herein, we review the key data pertaining to the use of PET-CT in the management of locally advanced esophageal and GEJ adenocarcinoma, with a focus on staging, prognostication, PET-CT adapted therapy in the neoadjuvant setting, and surveillance.
食管腺癌，包括胃食管交界腺癌，在美国并不常见，但在年轻成年人中的发病率呈上升趋势，且传统上预后较差。尽管针对局部晚期疾病的多模式治疗方法已取得了越来越多的益处，但大多数患者仍会发展为转移性疾病，长期预后仍然不理想。在过去十年中，正电子发射断层扫描-计算机断层扫描（PET-CT）已成为这种疾病管理的关键工具，有多项前瞻性和回顾性研究评估了其在该疾病中的作用。在此，我们回顾了与PET-CT在局部晚期食管和胃食管交界腺癌管理中的应用相关的关键数据，重点关注分期、预后评估、新辅助治疗中PET-CT适应性治疗以及监测。
