Brenes G, Dearwater S, Shapera R, LaPorte R E, Collins E
Arch Phys Med Rehabil. 1986 Jul;67(7):445-50.
Individuals with traumatic spinal cord injury (SCI) are extremely inactive yet little is known about the long-term consequences of chronic inactivity. Current research investigated the concentrations of high density lipoprotein cholesterol (HDLc) and its subfractions HDL2 and HDL3 in 66 extremely sedentary SCI admissions to a rehabilitation center. High density lipoprotein cholesterol is a primary risk factor for cardiovascular disease with decreased levels associated with increased cardiovascular risk. The concentrations of HDLc observed in the SCI sedentary population were compared with 22 olympic caliber wheelchair athletes (SCI athletes) and 126 able-bodied controls. Total HDLc, HDL2, and HDL3 was significantly lower in the male SCI sedentary population (34.2 mg/dl, 8.9 mg/dl, 25.3 mg/dl) than the male SCI athletes (42.7 mg/dl, 13.9 mg/dl, 28.8 mg/dl) or male able-bodied control populations (47.1mg/dl, 11.3mg/dl, 35.8 mg/dl). A similar pattern emerged for the female subjects. The reduction in HDLc seen in the SCI sedentary would predict over a 60% increased risk of heart attack compared to nondisabled controls. The primary difference between the two SCI groups was the level of physical activity, suggesting that this may be an important parameter for elevating total HDLc and HDL2, and presumably decreasing the risk for coronary heart disease. Therefore, physical activity positively affects total HDL and the supposedly antiatherogenic subfraction HDL2 in the SCI patient.
创伤性脊髓损伤（SCI）患者极度缺乏运动，但对于长期缺乏运动的后果却知之甚少。目前的研究调查了一家康复中心66名极度久坐的脊髓损伤患者高密度脂蛋白胆固醇（HDLc）及其亚组分HDL2和HDL3的浓度。高密度脂蛋白胆固醇是心血管疾病的主要危险因素，其水平降低与心血管风险增加相关。将脊髓损伤久坐人群中观察到的HDLc浓度与22名奥运水平的轮椅运动员（脊髓损伤运动员）和126名健全对照者进行比较。男性脊髓损伤久坐人群的总HDLc、HDL2和HDL3（分别为34.2mg/dl、8.9mg/dl、25.3mg/dl）显著低于男性脊髓损伤运动员（分别为42.7mg/dl、13.9mg/dl、28.8mg/dl）或男性健全对照人群（分别为47.1mg/dl、11.3mg/dl、35.8mg/dl）。女性受试者也出现了类似的模式。与非残疾对照者相比，脊髓损伤久坐人群中HDLc的降低预示着心脏病发作风险增加60%以上。两组脊髓损伤患者之间的主要差异在于身体活动水平，这表明身体活动水平可能是提高总HDLc和HDL2水平、进而降低冠心病风险的一个重要参数。因此，身体活动对脊髓损伤患者的总HDL以及可能具有抗动脉粥样硬化作用的亚组分HDL2有积极影响。
