Ambrosini-Spaltro Andrea, Di Donato Francesco, Saragoni Luca, Cserni Gábor, Rakha Emad, Foschini Maria Pia
Pathology Unit, Morgani-Pierantoni Hospital, AUSL Romagna, 47121 Forlì, Italy.
Pathology Unit, Santa Maria delle Croci Hospital, AUSL Romagna, 48121 Ravenna, Italy.
Cancers (Basel). 2023 May 31;15(11):3007. doi: 10.3390/cancers15113007.
(1) Background: The prognostic factors of microinvasive (≤1 mm) breast carcinoma are not completely clear. The aim of this study was to perform a systematic review and meta-analysis to clarify these factors. (2) Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology was followed. Two databases were interrogated, PubMed and Embase, and papers in English were included to address this question. The selected studies were those that reported on female patients affected by microinvasive carcinoma, and on prognostic factors with a hazard ratio (HR) for disease-free survival (DFS) and overall survival (OS). (3) Results: In total, 618 records were identified. After removing duplicates (166), identification, and screening (336 by title and abstract alone, 116 by full text and eventual supplementary material), 5 papers were selected. Seven different meta-analyses were conducted in this study, all referring to DFS, analyzing the following prognostic factors: estrogen receptor, progesterone receptor, HER2 status, multifocality and grade of microinvasion, patient's age, and lymph node status. Only lymph node status was associated with prognosis and DFS (total number of cases: 1528; Z = 1.94; = 0.05). The other factors examined did not significantly affect prognosis ( > 0.05). (4) Conclusions: Positive lymph node status significantly worsens prognosis in patients with microinvasive breast carcinoma.
(1) 背景：微浸润（≤1mm）乳腺癌的预后因素尚不完全清楚。本研究旨在进行系统评价和荟萃分析以阐明这些因素。(2) 方法：遵循系统评价和荟萃分析的首选报告项目（PRISMA）方法。检索了两个数据库，即PubMed和Embase，并纳入英文论文以解决该问题。所选研究为那些报告了受微浸润癌影响的女性患者以及无病生存期（DFS）和总生存期（OS）的风险比（HR）的预后因素的研究。(3) 结果：总共识别出618条记录。在去除重复项（166条）、识别和筛选（仅通过标题和摘要筛选336条，通过全文及最终补充材料筛选116条）后，选择了5篇论文。本研究进行了7项不同的荟萃分析，均涉及DFS，分析了以下预后因素：雌激素受体、孕激素受体、HER2状态、多灶性和微浸润分级、患者年龄以及淋巴结状态。只有淋巴结状态与预后和DFS相关（病例总数：1528；Z = 1.94；P = 0.05）。所检查的其他因素对预后无显著影响（P>0.05）。(4) 结论：微浸润性乳腺癌患者淋巴结阳性状态显著恶化预后。
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