Kram H B, Shoemaker W C, Bratanow N, Appel P L, Sterling R P, Fleming A W
Arch Surg. 1986 Aug;121(8):914-7. doi: 10.1001/archsurg.1986.01400080060010.
Conjunctival oxygen tension (PcjO2) was measured continuously during carotid endarterectomy in 15 patients to evaluate its sensitivity in patients receiving shunts. These studies suggest that PcjO2 tracks brain perfusion during periods of carotid artery occlusion. Reduced PcjO2 was clearly demonstrated with systemic hypotension, carotid artery clamping, and carotid shunt obstruction and clamping. Monitoring of PcjO2 is noninvasive, easy to perform, offers no danger to the patient, and allows real-time assessment of the local tissue perfusion. It provides valuable information on the effectiveness of carotid oxygen transport and, in conjunction with arterial blood gas values, expresses carotid artery perfusion relative to systemic oxygen transport. Further investigations using the PcjO2 sensor may define criteria for intraoperative carotid arterial shunting in patients with tenuous cerebral perfusion, and for prompt intervention in patients with deteriorating perfusion prior to the onset of life-threatening cerebral ischemia.
在15例患者行颈动脉内膜切除术期间连续测量结膜氧分压（PcjO2），以评估其在接受分流术患者中的敏感性。这些研究表明，在颈动脉闭塞期间，PcjO2可追踪脑灌注情况。全身性低血压、颈动脉夹闭以及颈动脉分流阻塞和夹闭均明显显示PcjO2降低。监测PcjO2是非侵入性的，易于操作，对患者无危险，并可实时评估局部组织灌注。它提供了关于颈动脉氧输送有效性的有价值信息，并与动脉血气值一起，表达相对于全身氧输送的颈动脉灌注情况。使用PcjO2传感器的进一步研究可能会确定脑灌注脆弱患者术中颈动脉分流的标准，以及在危及生命的脑缺血发作前对灌注恶化患者进行及时干预的标准。
