Gaillard Martin, Razafinimanana Meva, Challine Alexandre, Araujo Raphael L C, Libé Rossella, Sibony Mathilde, Barat Maxime, Bertherat Jérôme, Dousset Bertrand, Fuks David, Gaujoux Sebastien
Department of Digestive, Hepatobiliary and Endocrine Surgery, Hôpital Cochin, APHP.Centre, 75014 Paris, France.
Department of Digestive Surgery, Hôpital Saint-Antoine, APHP.Sorbonne Université, 75012 Paris, France.
J Clin Med. 2023 May 26;12(11):3698. doi: 10.3390/jcm12113698.
Surgical resection of adrenocortical carcinoma (ACC) is the only curative treatment. Even in localized (I-II) stages, open adrenalectomy (OA) is the gold standard, though laparoscopic adrenalectomy (LA) can be proposed in selected patients. Despite the postoperative benefits of LA, its role in the surgical management of patients with ACC remains controversial regarding oncologic outcomes. The aim of this retrospective study was to compare the outcomes of patients with localized ACC submitted to LA or OA in a referral center from 1995 to 2020. Among 180 consecutive patients operated on for ACC, 49 presented with localized ACC (19 LA and 30 OA). Baseline characteristics were similar between groups, except for tumor size. Kaplan-Meier estimates of 5-year overall survival were similar in both groups ( = 0.166) but 3-year disease-free survival was in favor of OA ( = 0.020). Though LA could be proposed in highly selected patients, OA should still be considered the standard approach in patients with known or suspected localized ACC.
肾上腺皮质癌（ACC）的手术切除是唯一的治愈性治疗方法。即使在局限性（I-II）期，开放性肾上腺切除术（OA）仍是金标准，不过对于部分患者可考虑行腹腔镜肾上腺切除术（LA）。尽管LA术后有诸多益处，但就肿瘤学结局而言，其在ACC患者手术治疗中的作用仍存在争议。这项回顾性研究的目的是比较1995年至2020年在一家转诊中心接受LA或OA治疗的局限性ACC患者的结局。在连续180例接受ACC手术的患者中，49例为局限性ACC（19例行LA，30例行OA）。除肿瘤大小外，两组的基线特征相似。两组的5年总生存Kaplan-Meier估计值相似（P = 0.
