Wiafe Yaw Amo, Afihene Mary Yeboah, Anto Enoch Odame, Nmai Richmond Ashitey, Amoah-Kumi Lois, Frimpong Joseph, Dickson Francis D, Antwi Samuel O, Roberts Lewis R
Department of Medical Diagnostics, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Department of Medicine, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
J Clin Med. 2023 May 29;12(11):3741. doi: 10.3390/jcm12113741.
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by hyperglycemia, insulin resistance, and pancreatic islet cell dysfunction. T2DM is associated with non-alcoholic fatty liver disease (NAFLD) because of impaired glucose metabolism in both conditions. However, it is widely assumed that people with T2DM in sub-Saharan Africa (SSA) have a lower prevalence of NAFLD than in other parts of the world. With our recent access to transient elastography, we aimed to investigate the prevalence of, severity of, and contributing factors to NAFLD in persons with T2DM in Ghana. We performed a cross-sectional study recruiting 218 individuals with T2DM at the Kwadaso Seventh-Day Adventist and Mount Sinai Hospitals in the Ashanti region of Ghana using a simple randomized sampling technique. A structured questionnaire was used to obtain socio-demographic information, clinical history, exercise and other lifestyle factors, and anthropometric measurements. Transient elastography was performed using a FibroScan machine to obtain the Controlled Attenuation Parameter (CAP) score and liver fibrosis score. The prevalence of NAFLD among Ghanaian T2DM participants was 51.4% (112/218), of whom 11.6% had significant liver fibrosis. An evaluation of the NAFLD group ( = 112) versus the non-NAFLD group ( = 106) revealed a higher BMI (28.7 vs. 25.2 kg/m, = 0.001), waist circumference (106.0 vs. 98.0 cm, = 0.001), hip circumference (107.0 vs. 100.5 cm, = 0.003), and waist-to-height ratio (0.66 vs. 0.62, = 0.001) in T2DM patients with NAFLD compared to those without NAFLD. Being obese was an independent predictor of NAFLD in persons with T2DM than known history of hypertension and dyslipidaemia.
2型糖尿病（T2DM）是一种代谢紊乱疾病，其特征为高血糖、胰岛素抵抗和胰岛细胞功能障碍。由于这两种疾病都存在葡萄糖代谢受损的情况，T2DM与非酒精性脂肪性肝病（NAFLD）相关。然而，人们普遍认为，撒哈拉以南非洲（SSA）的T2DM患者中NAFLD的患病率低于世界其他地区。随着我们最近能够使用瞬时弹性成像技术，我们旨在调查加纳T2DM患者中NAFLD的患病率、严重程度及相关因素。我们采用简单随机抽样技术，在加纳阿散蒂地区的夸达索基督复临安息日会医院和西奈山医院招募了218名T2DM患者，进行了一项横断面研究。使用结构化问卷获取社会人口统计学信息、临床病史、运动及其他生活方式因素以及人体测量数据。使用FibroScan机器进行瞬时弹性成像，以获得受控衰减参数（CAP）评分和肝纤维化评分。加纳T2DM参与者中NAFLD的患病率为51.4%（112/218），其中11.6%有显著肝纤维化。对NAFLD组（n = 112）与非NAFLD组（n = 106）进行评估发现，与无NAFLD的T2DM患者相比，有NAFLD的T2DM患者的体重指数更高（28.7 vs. 25.2 kg/m²，P = 0.001）、腰围更大（106.0 vs. 98.0 cm，P = 0.001）、臀围更大（107.0 vs. 100.5 cm，P = 0.003）以及腰高比更高（0.66 vs. 0.62，P = 0.001）。与已知的高血压和血脂异常病史相比，肥胖是T2DM患者中NAFLD的独立预测因素。
