Desai Geeta S, Hajare Santosh, Ghorpade Sandesha
Department of Gastroenterology and Hepatology, Karnatak Lingayat Education Society's (KLES) Dr. Prabhakar Kore Hospital and Medical Research Centre, KLE Academy of Higher Education and Research, Jawaharlal Nehru Medical College, Belagavi, IND.
Cureus. 2024 Aug 6;16(8):e66257. doi: 10.7759/cureus.66257. eCollection 2024 Aug.
India is currently facing an epidemic of type 2 diabetes mellitus (T2DM) and obesity which are high-risk factors for the development of non-alcoholic fatty liver disease (NAFLD). A non-invasive tool, the vibration-controlled transient elastography (VCTE; FibroScan, Echosens, Paris, France) is used to diagnose NAFLD.
To identify the prevalence, spectrum, and metabolic determinants of NAFLD in Indian adult women using liver function tests (LFT) and non-invasive FibroScan (liver stiffness measure, i.e., LSM score) of the liver through a cross-sectional population-based study in the city of Belagavi.
The subjects were screened for the presence of liver disease with a detailed history, anthropometric measurements, LFTs, blood sugars, and FibroScan of the liver to assess liver steatosis and liver fibrosis.
The study included 2448 women with 860 (35.13%) having NAFLD (controlled attenuation parameter {CAP}≥275 dB/m) as detected by FibroScan. Nearly, 58.8% of the participants with T2DM had NAFLD. Participants with NAFLD had higher BMI and waist circumference. When univariate logistic regression was applied, those with T2DM were 14.5 times (95% CI, 4.55, 6.52) likely to have CAP≥275 dB/m. Similarly, those with higher BMI>23 mg/m were 1.34 (95% CI, 1.68, 2.37) times more likely to have CAP ≥275 dB/m. The risk of NAFLD increases by ~1% for every one-year increase in age.
NAFLD in women is the most common non‑communicable disease in India; a prevalence of 35.13% was observed in the present study in women. Higher BMI, presence of metabolic risk factors, and incremental age were associated with a high risk of developing NAFLD in women.
印度目前正面临2型糖尿病（T2DM）和肥胖症的流行，这两种疾病是非酒精性脂肪性肝病（NAFLD）发展的高危因素。一种非侵入性工具，即振动控制瞬时弹性成像（VCTE；FibroScan，Echosens，法国巴黎），用于诊断NAFLD。
通过在贝拉尔加维市进行的一项基于人群的横断面研究，使用肝功能测试（LFT）和肝脏的非侵入性FibroScan（肝脏硬度测量，即LSM评分）来确定印度成年女性中NAFLD的患病率、范围和代谢决定因素。
通过详细的病史、人体测量、LFT、血糖和肝脏FibroScan对受试者进行肝病筛查，以评估肝脏脂肪变性和肝纤维化。
该研究纳入了2448名女性，其中860名（35.13%）经FibroScan检测患有NAFLD（控制衰减参数{CAP}≥275 dB/m）。近58.8%的T2DM参与者患有NAFLD。患有NAFLD的参与者BMI和腰围更高。应用单因素逻辑回归分析时，患有T2DM的人CAP≥275 dB/m的可能性是正常人的14.5倍（95%CI，4.55，6.52）。同样，BMI>23 mg/m的人CAP≥275 dB/m的可能性高1.34倍（95%CI，1.68，2.37）。年龄每增加一岁，患NAFLD的风险增加约1%。
女性NAFLD是印度最常见的非传染性疾病；在本研究中，女性的患病率为35.13%。较高的BMI、代谢危险因素的存在以及年龄的增加与女性患NAFLD的高风险相关。
