Department of Medical and Surgical Sciences, University of Bologna, 40126 Bologna, Italy.
Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.
Int J Mol Sci. 2023 May 28;24(11):9393. doi: 10.3390/ijms24119393.
Solute carriers (SLCs) are essential for brain physiology and homeostasis due to their role in transporting necessary substances across cell membranes. There is an increasing need to further unravel their pathophysiological implications since they have been proposed to play a pivotal role in brain tumor development, progression, and the formation of the tumor microenvironment (TME) through the upregulation and downregulation of various amino acid transporters. Due to their implication in malignancy and tumor progression, SLCs are currently positioned at the center of novel pharmacological targeting strategies and drug development. In this review, we discuss the key structural and functional characteristics of the main SLC family members involved in glioma pathogenesis, along with their potential targeting options to provide new opportunities for CNS drug design and more effective glioma management.
溶质载体（SLCs）在大脑生理学和动态平衡中起着重要作用，因为它们在将必需物质穿过细胞膜方面发挥作用。由于它们被提出在通过上调和下调各种氨基酸转运体在脑肿瘤发展、进展和肿瘤微环境（TME）形成中发挥关键作用，因此越来越需要进一步揭示其病理生理学意义。由于它们在恶性肿瘤和肿瘤进展中的意义，SLC 目前处于新型药理学靶向策略和药物开发的中心位置。在这篇综述中，我们讨论了参与神经胶质瘤发病机制的主要 SLC 家族成员的关键结构和功能特征，以及它们的潜在靶向选择，为 CNS 药物设计和更有效的神经胶质瘤管理提供了新的机会。
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