Department of Calcified Tissue Biology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima 734-8553, Japan.
Department of Bioproducts and Biosystems Engineering, University of Minnesota, 2004 Folwell Avenue, St. Paul, MN 55108, USA.
Int J Mol Sci. 2023 May 30;24(11):9464. doi: 10.3390/ijms24119464.
Promising scaffolds for developing advanced tissue engineering architectures have emerged in recent years through the use of nanofibers and 3D printing technologies. Despite this, structural integrity and cell proliferation are highlighted as fundamental challenges for design scaffolds and future prospects. As a biomimetic scaffold, the nanofiber-reinforced hydrogels demonstrated a better compressive modulus and cell growth. Our review focuses on recent promising advances in the development of 3D-printed hydrogels containing polymeric nanofibers that can improve cell-material interaction in biomedical applications. Moreover, an effort has been made to induce studies with diverse types of scaffolds for various cells. Additionally, we discuss the challenges and future prospects of 3D-bioprinted reinforced hydrogels with nanofibers in the medical field, as well as high-performance bioinks.
近年来，通过使用纳米纤维和 3D 打印技术，出现了有前途的用于开发先进组织工程结构的支架。尽管如此，结构完整性和细胞增殖仍是设计支架和未来前景的基本挑战。作为仿生支架，纳米纤维增强水凝胶表现出更好的压缩模量和细胞生长。我们的综述重点介绍了最近在开发含有聚合物纳米纤维的 3D 打印水凝胶方面的有前途的进展，这些水凝胶可改善生物医学应用中细胞与材料的相互作用。此外，还努力对各种细胞的各种类型的支架进行了研究。此外，我们还讨论了 3D 生物打印增强纳米纤维水凝胶在医学领域以及高性能生物墨水方面的挑战和未来前景。
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