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FeO 纳米材料影响肿瘤细胞铁死亡作用机制的研究进展。

Progress in the Mechanism of the Effect of FeO Nanomaterials on Ferroptosis in Tumor Cells.

机构信息

Health Science Center, Ningbo University, Ningbo 315211, China.

The First Affiliated Hospital of Ningbo University, Ningbo 315211, China.

出版信息

Molecules. 2023 Jun 5;28(11):4562. doi: 10.3390/molecules28114562.

DOI:10.3390/molecules28114562
PMID:37299036
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10254382/
Abstract

Ferroptosis is a new form of iron-dependent programmed cell death discovered in recent years, which is caused by the accumulation of lipid peroxidation (LPO) and reactive oxygen species (ROS). Recent studies have shown that cellular ferroptosis is closely related to tumor progression, and the induction of ferroptosis is a new means to inhibit tumor growth. Biocompatible FeO nanoparticles (FeO-NPs), rich in Fe and Fe, act as a supplier of iron ions, which not only promote ROS production but also participate in iron metabolism, thus affecting cellular ferroptosis. In addition, FeO-NPs combine with other techniques such as photodynamic therapy (PDT); heat stress and sonodynamic therapy (SDT) can further induce cellular ferroptosis effects, which then enhance the antitumor effects. In this paper, we present the research progress and the mechanism of FeO-NPs to induce ferroptosis in tumor cells from the perspective of related genes and chemotherapeutic drugs, as well as PDT, heat stress, and SDT techniques.

摘要

铁死亡是近年来发现的一种新的铁依赖性程序性细胞死亡形式，由脂质过氧化 (LPO) 和活性氧物种 (ROS) 的积累引起。最近的研究表明，细胞铁死亡与肿瘤进展密切相关，诱导铁死亡是抑制肿瘤生长的新手段。生物相容性的 FeO 纳米颗粒 (FeO-NPs) 富含 Fe 和 Fe，充当铁离子的供应源，不仅促进 ROS 的产生，而且参与铁代谢，从而影响细胞铁死亡。此外，FeO-NPs 与光动力疗法 (PDT) 等其他技术结合；热应激和声动力疗法 (SDT) 可以进一步诱导细胞铁死亡效应，从而增强抗肿瘤作用。本文从相关基因和化疗药物以及 PDT、热应激和 SDT 技术的角度，介绍了 FeO-NPs 诱导肿瘤细胞铁死亡的研究进展及其机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f9f/10254382/04effbada6c2/molecules-28-04562-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f9f/10254382/68e9da793fb9/molecules-28-04562-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f9f/10254382/468ec13fa081/molecules-28-04562-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f9f/10254382/939ab3b03011/molecules-28-04562-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f9f/10254382/71a95e45e605/molecules-28-04562-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f9f/10254382/e1fb2b610d6b/molecules-28-04562-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f9f/10254382/31664b7637d9/molecules-28-04562-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f9f/10254382/20c9d5f182e9/molecules-28-04562-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f9f/10254382/04effbada6c2/molecules-28-04562-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f9f/10254382/68e9da793fb9/molecules-28-04562-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f9f/10254382/468ec13fa081/molecules-28-04562-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f9f/10254382/939ab3b03011/molecules-28-04562-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f9f/10254382/71a95e45e605/molecules-28-04562-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f9f/10254382/e1fb2b610d6b/molecules-28-04562-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f9f/10254382/31664b7637d9/molecules-28-04562-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f9f/10254382/20c9d5f182e9/molecules-28-04562-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f9f/10254382/04effbada6c2/molecules-28-04562-g008.jpg

相似文献

[1]
Progress in the Mechanism of the Effect of FeO Nanomaterials on Ferroptosis in Tumor Cells.

Molecules. 2023-6-5

[2]
Complementing Cancer Photodynamic Therapy with Ferroptosis through Iron Oxide Loaded Porphyrin-Grafted Lipid Nanoparticles.

ACS Nano. 2021-12-28

[3]
Iron oxide@chlorophyll clustered nanoparticles eliminate bladder cancer by photodynamic immunotherapy-initiated ferroptosis and immunostimulation.

J Nanobiotechnology. 2022-8-11

[4]
Fe/Fe Ions Chelated with Ultrasmall Polydopamine Nanoparticles Induce Ferroptosis for Cancer Therapy.

ACS Biomater Sci Eng. 2019-9-9

[5]
Multifunctional FeO-PEI@HA nanoparticles in the ferroptosis treatment of hepatocellular carcinoma through modulating reactive oxygen species.

Colloids Surf B Biointerfaces. 2023-7

[6]
'Mito-Bomb': a novel mitochondria-targeting nanosystem for ferroptosis-boosted sonodynamic antitumor therapy.

Drug Deliv. 2022-12

[7]
Photodynamic Therapy Combined with Ferroptosis Is a Synergistic Antitumor Therapy Strategy.

Cancers (Basel). 2023-10-19

[8]
Iron-based nanoparticles for MR imaging-guided ferroptosis in combination with photodynamic therapy to enhance cancer treatment.

Nanoscale. 2021-3-12

[9]
Iron oxide nanoparticles cause surface coating- and core chemistry-dependent endothelial cell ferroptosis.

Nanotoxicology. 2022

[10]
Synergistic therapy for orthotopic gliomas biomimetic nanosonosensitizer-mediated sonodynamic therapy and ferroptosis.

Biomater Sci. 2022-7-12

引用本文的文献

[1]
Recent research progress on metal ions and metal-based nanomaterials in tumor therapy.

Front Bioeng Biotechnol. 2025-2-7

[2]
Photothermal FeO nanoparticles induced immunogenic ferroptosis for synergistic colorectal cancer therapy.

J Nanobiotechnology. 2024-10-16

[3]
Ferroptosis resistance in cancer cells: nanoparticles for combination therapy as a solution.

Front Pharmacol. 2024-6-19

[4]
Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches.

Drug Des Devel Ther. 2024

本文引用的文献

[1]
p53 Promotes Ferroptosis in Macrophages Treated with FeO Nanoparticles.

ACS Appl Mater Interfaces. 2022-9-28

[2]
Folate-modified erythrocyte membrane nanoparticles loaded with FeO and artemisinin enhance ferroptosis of tumors by low-intensity focused ultrasound.

Front Oncol. 2022-8-10

[3]
Synergistic therapy for orthotopic gliomas biomimetic nanosonosensitizer-mediated sonodynamic therapy and ferroptosis.

Biomater Sci. 2022-7-12

[4]
Ferroptosis-Driven Nanotherapeutics to Reverse Drug Resistance in Tumor Microenvironment.

ACS Appl Bio Mater. 2022-6-20

[5]
Homogenous multifunctional microspheres induce ferroptosis to promote the anti-hepatocarcinoma effect of chemoembolization.

J Nanobiotechnology. 2022-4-2

[6]
Biomimetic GBM-targeted drug delivery system boosting ferroptosis for immunotherapy of orthotopic drug-resistant GBM.

J Nanobiotechnology. 2022-3-27

[7]
Appropriate Size of FeO Nanoparticles for Cancer Therapy by Ferroptosis.

ACS Appl Bio Mater. 2022-4-18

[8]
Peroxidase-like Active Nanomedicine with Dual Glutathione Depletion Property to Restore Oxaliplatin Chemosensitivity and Promote Programmed Cell Death.

ACS Nano. 2022-3-22

[9]
Two-Photon Fluorescent Nanomaterials and Their Applications in Biomedicine.

J Biomed Nanotechnol. 2021-4-1

[10]
An active-passive strategy for enhanced synergistic photothermal-ferroptosis therapy in the NIR-I/II biowindows.

Biomater Sci. 2022-2-15

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