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壳聚糖基水凝胶的合成、表征、性质及生物医学应用

Synthesis, Characterization, Properties, and Biomedical Application of Chitosan-Based Hydrogels.

作者信息

Ye Ruixi, Liu Siyu, Zhu Wenkai, Li Yurong, Huang Long, Zhang Guozheng, Zhang Yeshun

机构信息

College of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang 212100, China.

Key Laboratory of Silkworm and Mulberry Genetic Improvement, Ministry of Agriculture and Rural Affairs, Sericultural Research Institute, Chinese Academy of Agricultural Sciences, Zhenjiang 212100, China.

出版信息

Polymers (Basel). 2023 May 27;15(11):2482. doi: 10.3390/polym15112482.

Abstract

The prospective applications of chitosan-based hydrogels (CBHs), a category of biocompatible and biodegradable materials, in biomedical disciplines such as tissue engineering, wound healing, drug delivery, and biosensing have garnered great interest. The synthesis and characterization processes used to create CBHs play a significant role in determining their characteristics and effectiveness. The qualities of CBHs might be greatly influenced by tailoring the manufacturing method to get certain traits, including porosity, swelling, mechanical strength, and bioactivity. Additionally, characterization methods aid in gaining access to the microstructures and properties of CBHs. Herein, this review provides a comprehensive assessment of the state-of-the-art with a focus on the affiliation between particular properties and domains in biomedicine. Moreover, this review highlights the beneficial properties and wide application of stimuli-responsive CBHs. The main obstacles and prospects for the future of CBH development for biomedical applications are also covered in this review.

摘要

壳聚糖基水凝胶(CBHs)作为一类生物相容性和可生物降解的材料,在组织工程、伤口愈合、药物递送和生物传感等生物医学领域的潜在应用引起了极大的关注。用于制备CBHs的合成和表征过程在决定其特性和有效性方面起着重要作用。通过调整制造方法以获得某些特性,如孔隙率、溶胀性、机械强度和生物活性,可能会极大地影响CBHs的质量。此外,表征方法有助于了解CBHs的微观结构和性质。在此,本综述对当前的研究现状进行了全面评估,重点关注特定性质与生物医学领域之间的关联。此外,本综述还强调了刺激响应性CBHs的有益特性和广泛应用。本综述还涵盖了CBHs在生物医学应用开发方面未来面临的主要障碍和前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf41/10255636/7f14ed828670/polymers-15-02482-g001.jpg

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