Determination of the molecular size of the hepatic H1-receptor by target size analysis.
作者信息
Wang N P, Fukui H, Matsuoka H, Wada H
出版信息
Biochem Biophys Res Commun. 1986 Jun 13;137(2):593-8. doi: 10.1016/0006-291x(86)91119-8.
PMID:3729930
Abstract
The molecular sizes of histamine H1-receptors of rat, rabbit, human, pig, guinea-pig, chicken, dog, and bovine liver were investigated by radiation inactivation and determined to be 100,000 to 160,000 daltons in all the animals examined. Statistical analysis showed that the hepatic H1-receptors have a common size of 128,000 +/- 63,000 daltons. Saturation analysis showed that the [3H]mepyramine binding constant was not changed by irradiation, while the binding capacity decreased with increase in the radiation dose.
摘要
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引用本文的文献
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