Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100190, China.
National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Nutrients. 2023 Jun 1;15(11):2605. doi: 10.3390/nu15112605.
Hematopoietic stem cells (HSCs) are crucial for the life maintenance of bio-organisms. However, the mechanism of HSC regulation is intricate. Studies have shown that there are various factors, either intrinsically or extrinsically, that shape the profile of HSCs. This review systematically summarizes the intrinsic factors (i.e., RNA-binding protein, modulators in epigenetics and enhancer-promotor-mediated transcription) that are reported to play a pivotal role in the function of HSCs, therapies for bone marrow transplantation, and the relationship between HSCs and autoimmune diseases. It also demonstrates the current studies on the effects of high-fat diets and nutrients (i.e., vitamins, amino acids, probiotics and prebiotics) on regulating HSCs, providing a deep insight into the future HSC research.
造血干细胞（HSCs）对于生物机体的生命维持至关重要。然而，HSC 的调控机制非常复杂。研究表明，有各种内在或外在的因素影响 HSC 的特征。本综述系统地总结了内在因素（即 RNA 结合蛋白、表观遗传学调节剂和增强子-启动子介导的转录），这些因素被报道在 HSC 的功能、骨髓移植治疗以及 HSC 与自身免疫性疾病的关系中发挥关键作用。还展示了关于高脂肪饮食和营养素（即维生素、氨基酸、益生菌和益生元）对 HSCs 调节作用的当前研究，为未来的 HSC 研究提供了深入的见解。
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