College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
Institute of Translational Medicine, The First Affiliated Hospital (Shenzhen Second People's Hospital), Shenzhen University, Health Science Center, Shenzhen 518060, China.
Sensors (Basel). 2023 Jun 2;23(11):5280. doi: 10.3390/s23115280.
As one of the most well-established biocompatible transition metal nitrides, titanium nitride (TiN) has been widely applied for fiber waveguide coupling device applications. This study proposes a TiN-modified fiber optic interferometer. Benefiting from the unique properties of TiN, including ultrathin nanolayer, high refractive index, and broad-spectrum optical absorption, the refractive index (RI) response of the interferometer is greatly enhanced, which is desired all the time in the field of biosensing. The experimental results show that the deposited TiN nanoparticles (NPs) can enhance the evanescent field excitation and modulate the effective RI difference of the interferometer, which eventually results in the RI response enhancement. Besides, after incorporating the TiN with different concentrations, the resonant wavelength and the RI responses of the interferometer are enhanced to varying degrees. Benefitting from this advantage, the sensing performances, including sensitivity and measurement range, can be flexibly adapted based on different detection requirements. Since RI response can effectively reflect the detection ability of biosensors, the proposed TiN-sensitized fiber optic interferometer can be potentially applied for high-sensitive biosensing applications.
作为最成熟的生物相容性过渡金属氮化物之一，氮化钛（TiN）已广泛应用于光纤波导耦合器件。本研究提出了一种 TiN 修饰的光纤干涉仪。TiN 的独特性质，包括超薄纳米层、高折射率和宽光谱光吸收，使干涉仪的折射率（RI）响应得到极大增强，这是生物传感领域一直以来所期望的。实验结果表明，沉积的 TiN 纳米颗粒（NPs）可以增强消逝场激发并调制干涉仪的有效 RI 差，从而最终增强 RI 响应。此外，掺入不同浓度的 TiN 后，干涉仪的共振波长和 RI 响应都得到了不同程度的增强。由于这种优势，传感性能，包括灵敏度和测量范围，可以根据不同的检测要求灵活适应。由于 RI 响应可以有效地反映生物传感器的检测能力，因此所提出的 TiN 敏化光纤干涉仪可潜在地应用于高灵敏度生物传感应用。
