Erkkola R, Viikari J, Irjala K, Solakivi-Jaakkola T
Biol Res Pregnancy Perinatol. 1986;7(2):47-51.
Serum lipid and lipoprotein fractions one day after delivery, 3 months later in lactating and nonlactating mothers and 12 months later after initiation of menstruation were investigated in a group of 62 women, 29 of which formed a truly longitudinal group. Total serum cholesterol decreased significantly within 3 months after delivery and a further significant decrease occurred during the following 9 months. LDL- and HDL-cholesterols showed also a significant decrease within the postpartal year. Serum triglycerides decreased within 3 months after delivery but no more significantly later. Apolipoprotein AI and B also decreased within 3 months after delivery. In lactating mothers, HDL-cholesterol: cholesterol ratio, apolipoprotein AI and apolipoprotein AI:B ratio were higher than in nonlactating women. During the luteal phase, serum cholesterol and LDL-cholesterol were lower and the HDL-cholesterol: cholesterol ratio was higher than earlier during the menstrual cycle. Data prove that pregnancy related changes in lipid metabolism did not wane within 3 months after delivery. They also show that lactation affects lipid metabolism.
对62名女性进行了研究，观察她们产后1天、产后3个月（分为哺乳期和非哺乳期母亲）以及月经初潮后12个月时的血脂和脂蛋白组分，其中29名女性构成了一个真正的纵向研究组。产后3个月内，血清总胆固醇显著下降，在接下来的9个月中进一步显著下降。低密度脂蛋白胆固醇（LDL-胆固醇）和高密度脂蛋白胆固醇（HDL-胆固醇）在产后1年内也显著下降。血清甘油三酯在产后3个月内下降，但之后不再显著下降。载脂蛋白AI和B在产后3个月内也下降。哺乳期母亲的HDL-胆固醇与胆固醇比值、载脂蛋白AI以及载脂蛋白AI与B的比值高于非哺乳期女性。在黄体期，血清胆固醇和LDL-胆固醇较低，HDL-胆固醇与胆固醇比值高于月经周期早期。数据证明，与妊娠相关的脂质代谢变化在产后3个月内并未减弱。研究还表明，哺乳会影响脂质代谢。
