Aiache J M, Faurie M, Sibaud Y, Kaftelip J P, Aiache S
Biopharm Drug Dispos. 1986 May-Jun;7(3):301-7. doi: 10.1002/bdd.2510070311.
In order to evaluate the influence of food and time of administration on the absorption of diethylamine chromocarbe, a bioavailability study was performed in 8 volunteers by using a new method of plasmatic drug evaluation. The results obtained indicate that lunch has little effect on diethylamine chromocarbe absorption in comparison with the administration 0.5 h before breakfast. The bioavailability parameters Cmax, tmax, and AUC are not statistically different and the two methods of administration can be considered as bioequivalent. The absorption of diethylamine chromocarbe seems to be reduced when the drug is administered before dinner. This delay on absorption may be due to circadian rhythm of tractus gastrointestinal absorption or to the reduction of physiological activity of volunteers.
为了评估食物和给药时间对二乙胺色甘酸盐吸收的影响，采用一种新的血浆药物评估方法，对8名志愿者进行了生物利用度研究。所得结果表明，与早餐前0.5小时给药相比，午餐对二乙胺色甘酸盐的吸收影响很小。生物利用度参数Cmax、tmax和AUC在统计学上无差异，两种给药方法可视为生物等效。当药物在晚餐前给药时，二乙胺色甘酸盐的吸收似乎会降低。这种吸收延迟可能是由于胃肠道吸收的昼夜节律或志愿者生理活性的降低。
