[向大鼠脑室微量注射血管紧张素II和缓激肽以及向眼结膜滴注后大鼠饮水行为的比较分析]
[Comparative analysis of the drinking behavior of rats after microinjections of angiotensin II and bradykinin into the cerebral ventricles and instillations on the conjunctiva of the eye].
作者信息
Kelesheva L F
出版信息
Biull Eksp Biol Med. 1986 Jun;101(6):709-12.
PMID:3730560
Abstract
The effects of angiotensin-II and bradykinin intracerebroventricular microinjections and instillations on the conjunctiva on water and alcohol consumption in rats were compared. The identical effects of peptide instillations on the conjunctiva and intracerebroventricular microinjections were demonstrated. Dipsogenic doses of angiotensin-II for instillations on the conjunctiva in intact rats were greater than or equal to 10 micrograms. At the same time the effective peptide doses in drinking rats were similar to intracerebroventricular drug doses.
摘要
比较了血管紧张素-II和缓激肽脑室内微量注射及结膜滴注对大鼠饮水和酒精消耗的影响。结果表明，肽类物质结膜滴注和脑室内微量注射具有相同的作用。完整大鼠结膜滴注血管紧张素-II产生致渴作用的剂量大于或等于10微克。同时，在饮水大鼠中有效肽剂量与脑室内给药剂量相似。
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