伴有特定突变的胃间质瘤对新辅助伊马替尼的病理完全缓解：1例报告及文献复习
Pathologic complete response to neoadjuvant imatinib of a gastric stromal tumor with concomitant mutations in : A case report and literature review.
作者信息
Rekaya Mariem Ben, Ksontini Feryel, Kacem Linda Bel Haj, Sassi Farah, Harigua-Souiai Emna, Boujneh Ryma, H'mayada Ahmed, Zaimi Yosra, Ayadi Mouna, Trabelsi Mediha, Mrad Ridha, Rammeh Soumaya
机构信息
Theranostic Biomarkers, UR17ES15, Faculty of Medicine of Tunis Université Tunis El Manar Tunis Tunisia.
Pathology Department Charles Nicolle Hospital Tunis Tunisia.
出版信息
Clin Case Rep. 2023 Jun 7;11(6):e7463. doi: 10.1002/ccr3.7463. eCollection 2023 Jun.
KEY CLINICAL MESSAGE
We report the first case of pathologic complete response (pCR) to neoadjuvant imatinib in a gastric stromal tumor harboring mutations in both exons 11 and 9. The significance of this co-occurrence is unknown and might increase the responsiveness of gastrointestinal stromal tumors (GISTs) to imatinib.
ABSTRACT
pCR of GIST to neoadjuvant imatinib is rare. We report a case of pCR to neoadjuvant imatinib in a gastric stromal tumor that harbored co-occurrence of multiple mutations in exons 11 and 9. This co-occurrence in exons 9 and 11 is the first to be reported in the English literature.
关键临床信息
我们报告了首例胃间质瘤对新辅助伊马替尼治疗达到病理完全缓解（pCR）的病例，该病例的第11外显子和第9外显子均存在突变。这种共同出现的意义尚不清楚，可能会增加胃肠道间质瘤（GIST）对伊马替尼的反应性。
摘要
GIST对新辅助伊马替尼治疗达到pCR的情况较为罕见。我们报告了一例胃间质瘤对新辅助伊马替尼治疗达到pCR的病例，该病例第11外显子和第9外显子同时存在多个突变。第9外显子和第11外显子的这种共同出现情况在英文文献中尚属首次报道。
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