毛细胞白血病（HCL）中自然杀伤细胞（NK）活性降低：细胞水平分析
Decreased NK activity in hairy cell leukemia (HCL): an analysis at the cellular level.
作者信息
Fontana L, De Rossi G, De Sanctis G, Ensoli F, Lopez M, Annino L, Mandelli F
出版信息
Blut. 1986 Aug;53(2):107-13. doi: 10.1007/BF00321093.
Peripheral blood lymphocytes (PBL) of eleven patients with Hairy Cell Leukemia were studied for surface phenotype and for NK activity against the K 562 cell line (using both the standard 51Cr Release Assay and the Single Cell Cytotoxicity Assay on poly-L-lysine coated coverslips). A significant reduction in NK activity, target binding cells (TBC) and NK active cells (NKa) was detected. In some cases however, despite a very low percentage of NKa, residual NK activity was observed, suggesting an efficient recycling capacity.
对11例毛细胞白血病患者的外周血淋巴细胞（PBL）进行了表面表型分析，并检测了其对K562细胞系的自然杀伤（NK）活性（同时采用标准的51Cr释放试验和在聚-L-赖氨酸包被的盖玻片上进行的单细胞细胞毒性试验）。检测到NK活性、靶细胞结合细胞（TBC）和NK活性细胞（NKa）显著降低。然而，在某些情况下，尽管NKa的比例非常低，但仍观察到残余的NK活性，提示存在有效的再循环能力。
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