FSO 引发的两种不同烯烃的串联加成反应：一种获得多功能脂肪族磺酰氟的简便方法。
FSO Radical-Initiated Tandem Addition Reaction of Two Different Olefins: A Facile Access to Multifunctional Aliphatic Sulfonyl Fluorides.
机构信息
Key Laboratory of Molecule Synthesis and Function Discovery, College of Chemistry, Fuzhou University, 2 Xueyuan Road, Fuzhou 350116, P. R. China.
State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen 361005, P. R. China.
出版信息
Org Lett. 2023 Jun 23;25(24):4478-4482. doi: 10.1021/acs.orglett.3c01491. Epub 2023 Jun 12.
Multicomponent reactions represent a powerful method for building complex molecules from structurally simple starting materials. Herein, we report a novel three-component radical-polar crossover reaction involving a tandem addition reaction of two different olefins, which is initiated by the selective addition of fluorosulfonyl radicals to alkyl alkenes. This tandem process provides facile and effective access to multiple functionalized aliphatic sulfonyl fluoride molecules. Further transformation of the products is also demonstrated.
多组分反应是一种从结构简单的起始原料构建复杂分子的强大方法。在此，我们报告了一种新颖的三组分自由基-极性交叉反应，涉及两种不同烯烃的串联加成反应，该反应由氟磺酰基自由基选择性加成到烷基烯烃引发。这种串联过程提供了一种简便有效的方法来获得多种官能化的脂肪族磺酰氟分子。还展示了产物的进一步转化。
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