Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Pol J Pathol. 2023;74(1):42-50. doi: 10.5114/pjp.2023.127265.
Obg-like ATPase 1 (OLA1) is a member of the Obg family of P-loop NTPases and has recently been detected in several human cancer cells. However, its expression type and clinical relevance in gastric cancer remains unclear. In the present study, mRNA level of OLA1 in gastric cancer (GC) was detected in 2 datasets downloaded from the open Gene Expression Omnibus database and 30 cancer tissues. Immunohistochemistry was performed on GC and its association with Snail in 334 GC patients. The results showed that OLA1 mRNA and protein were elevated in GC tissues. High expression of OLA1 was significantly associated with aggressive features, such as tumour size, lymph-node-metastasis and tumour-nodus-metastases stage ( p = 0.0146, p = 0.0037, p < 0.001, respectively). Moreover, high levels of OLA1 predicted worse overall survival. Multivariate Cox regression analysis indicated that high expression of OLA1 was an independent prognostic factor for poor overall survival ( p = 0.009). Additionally, OLA1 expression was positively correlated with Snail, and a combination of them revealed improved prognostic accuracy for GC patients. High expression of OLA1 predicts poor prognosis in GC patients and may be serviced as a novel target for GC.
Obg 样 ATP 酶 1（OLA1）是 P 环 NTP 酶 Obg 家族的成员，最近在几种人类癌细胞中被检测到。然而，其在胃癌中的表达类型和临床相关性尚不清楚。本研究从公开的基因表达综合数据库中下载的 2 个数据集和 30 个癌组织中检测了胃癌（GC）中 OLA1 的 mRNA 水平。对 334 例 GC 患者的 GC 组织进行了免疫组织化学分析，并与 Snail 进行了关联分析。结果表明，GC 组织中 OLA1 mRNA 和蛋白表达升高。OLA1 的高表达与侵袭性特征显著相关，如肿瘤大小、淋巴结转移和肿瘤-淋巴结-转移分期（p=0.0146，p=0.0037，p<0.001）。此外，高水平的 OLA1 预示着总生存率较差。多因素 Cox 回归分析表明，OLA1 高表达是总生存率不良的独立预后因素（p=0.009）。此外，OLA1 表达与 Snail 呈正相关，两者结合可提高 GC 患者的预后准确性。OLA1 的高表达预示着 GC 患者预后不良，可能成为 GC 的新治疗靶点。
