Laboratorio de Antimutagénesis, Anticarcinogénesis Y Antiteratogénesis Ambiental, Facultad de Estudios Superiores-Zaragoza, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico.
Unidad de Investigación En Gerontología, Facultad de Estudios Superiores-Zaragoza, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico.
J Toxicol Environ Health B Crit Rev. 2023 Oct 3;26(7):371-386. doi: 10.1080/10937404.2023.2224119. Epub 2023 Jun 12.
This review is based upon evidence from the published effects of green tea polyphenols (GTP) on genotoxic damage induced by metals with carcinogenic potential. First, the relationship between GTP and antioxidant defense system is provided. Subsequently, the processes involved in the oxidative stress generated by metals and their relationship to oxidative DNA damage is examined. The review demonstrated that GTP generally decrease oxidative DNA damage induced by exposure to metals such as arsenic (As), cadmium (Cd), cobalt (Co), copper (Cu), chromium (Cr), iron (Fe), and lead (Pb). The pathways involved in these effects are related to: (1) direct scavenging of free radicals (FR); (2) activation of mechanisms to repair oxidative DNA damage; (3) regulation of the endogenous antioxidant system; and (4) elimination of cells with genetic damage via apoptosis. The results obtained in the studies reviewed demonstrate potential for possible use of GTP to prevent and treat oxidative damage in populations exposed to metals. Further, GTP may be considered as adjuvants to treatments for metal-associated diseases related to oxidative stress and DNA damage.
这篇综述基于绿茶多酚（GTP）对具有致癌潜力的金属诱导的遗传毒性损伤的已发表影响的证据。首先，提供了 GTP 与抗氧化防御系统之间的关系。随后，检查了金属产生的氧化应激过程及其与氧化 DNA 损伤的关系。综述表明，GTP 通常可降低砷（As）、镉（Cd）、钴（Co）、铜（Cu）、铬（Cr）、铁（Fe）和铅（Pb）等金属暴露引起的氧化 DNA 损伤。这些作用的途径与：（1）直接清除自由基（FR）；（2）激活修复氧化 DNA 损伤的机制；（3）调节内源性抗氧化系统；以及（4）通过细胞凋亡消除具有遗传损伤的细胞。综述中获得的结果表明，GTP 可能有潜力用于预防和治疗接触金属的人群中的氧化损伤。此外，GTP 可被视为与氧化应激和 DNA 损伤相关的金属相关疾病治疗的佐剂。
