大鼠离体输精管对乙醇抑制作用耐受性的发展：体内急性和慢性给予乙醇的影响。
Development of tolerance to the inhibitory effects of ethanol in the rat isolated vas deferens: effect of acute and chronic ethanol administration in vivo.
作者信息
DeTurck K H, Pohorecky L A
出版信息
Br J Pharmacol. 1986 Jun;88(2):397-403. doi: 10.1111/j.1476-5381.1986.tb10216.x.
Contractions of the rat vas deferens elicited by the addition of noradrenaline (NA), K+-depolarizing solutions or by electrical stimulation were recorded before and after incubation with ethanol 181 mM. In tissues from untreated rats, the contractions were inhibited 40-50% by such exposure. Injection of ethanol (2 g kg-1) significantly attenuated ethanol's reduction of peak tension generated by the lowest concentration of NA (10(-4) mM). Chronic administration of ethanol, 18-14 g kg-1 daily for two weeks, resulted in significant tolerance to ethanol. Tissues of treated animals demonstrated ethanol-induced decreases of roughly one-half those of the maltose dextrin (isocaloric) and water (fluid control) groups. This tolerance persisted for at least 48 h after ethanol treatment had been terminated. Overall, the data suggest that ethanol acts both pre- and postsynaptically to produce acute inhibition of smooth muscle contractions or tolerance to these actions upon chronic exposure.
在与181 mM乙醇孵育前后，记录添加去甲肾上腺素（NA）、K⁺去极化溶液或电刺激引起的大鼠输精管收缩情况。在未处理大鼠的组织中，这种暴露可使收缩抑制40 - 50%。注射乙醇（2 g/kg）可显著减弱乙醇对最低浓度NA（10⁻⁴ mM）产生的峰值张力的降低作用。每天给予18 - 14 g/kg乙醇，持续两周的慢性给药导致对乙醇产生显著耐受性。处理动物的组织显示，乙醇引起的降低幅度约为麦芽糖糊精（等热量）和水（液体对照）组的一半。在乙醇处理终止后，这种耐受性至少持续48小时。总体而言，数据表明乙醇在突触前和突触后均起作用，以产生对平滑肌收缩的急性抑制或在长期暴露后对这些作用产生耐受性。
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