Association between Lactate Dehydrogenase and 30-Day Mortality in Patients with Sepsis: a Retrospective Cohort Study.

BACKGROUND

Sepsis is one of the major causes of death in intensive care unit patients, so it is urgent to explore indicators for rapid and effective screening of sepsis mortality risk. The purpose of this study is to explore the association of LDH level with 30-day mortality in sepsis patients to improve patient survival outcomes.

METHODS

In this retrospective cohort study, a total of 5,275 patients with sepsis from the Medical Information Mart for Intensive Care IV (MIMIC-IV). LDH level at admission was obtained, and the outcome indicator was the 30-day mortality. Multivariate Cox regression and Kaplan-Meier survival curve analysis were used to assess the relationship between LDH level and 30-day mortality in patients with sepsis.

RESULTS

A total of 5,275 patients with sepsis were screened, the 30-day mortality was 51.5%. In multivariate regression models, hazard ratio [HR] and 95% confidence interval [CI] for Log2 and LDH ≥ 250 UI/L were 1.33 (1.29 - 1.37) and 1.69 (1.54 - 1.85), respectively. Kaplan-Meier survival curve analysis suggested that LDH level is associated with prognosis in patients with sepsis.

CONCLUSIONS

LDH level was associated with 30-day mortality, which can be used as an important predictor of clinical outcomes for patients.