Department of Gynecology, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Department of Gynecology, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Division of Uterine Vascular Biology, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, 510623, China.
Placenta. 2023 Sep 26;141:51-56. doi: 10.1016/j.placenta.2023.05.013. Epub 2023 May 24.
Spiral artery remodeling is the process by which the uterine vessels become large bore low resistance conduits, allowing delivery of high volumes of maternal blood to the placenta to nourish the developing fetus. Failure of this process is associated with the pathophysiology of most of the major obstetric complications, including late miscarriage, fetal growth restriction and pre-eclampsia. However, the point at which remodeling 'fails' in these pathological pregnancies is not yet clear. Spiral artery remodeling has predominantly been described in terms of its morphological features, however we are starting to understand more about the cellular and molecular triggers of the different aspects of this process. This review will discuss the current state of knowledge of spiral artery remodeling, in particular the processes involved in loss of the vascular smooth muscle cells, and consider where in the process defects would lead to a pathological pregnancy.
螺旋动脉重塑是子宫血管变成大口径、低阻力导管的过程，使大量的母体血液输送到胎盘，以滋养发育中的胎儿。这个过程的失败与大多数主要产科并发症的病理生理学有关，包括晚期流产、胎儿生长受限和子痫前期。然而，在这些病理性妊娠中，重塑“失败”的时间点尚不清楚。螺旋动脉重塑主要是根据其形态学特征来描述的，但是我们开始更多地了解这个过程的不同方面的细胞和分子触发因素。这篇综述将讨论螺旋动脉重塑的现有知识状态，特别是涉及血管平滑肌细胞丧失的过程，并考虑在这个过程中缺陷会导致病理性妊娠的位置。
