Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, Tottori 680-8552, Japan.
Department of Bioresources Science, Graduate School of Agricultural Sciences, Tottori University, Tottori 680-8553, Japan.
J Mater Chem B. 2023 Jul 5;11(26):6053-6059. doi: 10.1039/d3tb00169e.
Tumor-specific drug-delivering nanocarriers could be a promising modality for next-generation tumor therapy. Here we developed a Burkitt lymphoma-specific DNA aptamer-labeled nanocarrier using the β-Annulus peptide, which forms a spherical nanoassembly called artificial viral capsid. Dynamic light scattering and transmission electron microscopy of the DNA aptamer-decorated artificial viral capsid showed the formation of spherical assemblies with a diameter of approximately 50-150 nm. The artificial viral capsid was selectively internalized into the Burkitt lymphoma cell line, Daudi, and doxorubicin complexed with the capsid selectively killed Daudi cells.
肿瘤特异性药物递送纳米载体可能是下一代肿瘤治疗的一种有前途的方式。在这里，我们使用β-Annulus 肽开发了一种伯基特淋巴瘤特异性 DNA 适体标记的纳米载体，该肽形成一种称为人工病毒衣壳的球形纳米组装体。DNA 适体修饰的人工病毒衣壳的动态光散射和透射电子显微镜显示，形成了直径约为 50-150nm 的球形组装体。人工病毒衣壳选择性地被内化进入伯基特淋巴瘤细胞系 Daudi，并且与衣壳结合的阿霉素选择性地杀死 Daudi 细胞。
