Salem P, Anaissie E, Allam C, Geha S, Hashimi L, Ibrahim N, Jabbour J, Habboubi N, Khalyl M
Cancer. 1986 Sep 1;58(5):1162-6. doi: 10.1002/1097-0142(19860901)58:5<1162::aid-cncr2820580531>3.0.co;2-8.
A total of 417 evaluable patients with non-Hodgkin's lymphomas were diagnosed between January 1974 and December 1983 at the American University of Beirut Medical Center in Beirut, Lebanon. Of these, 179 (43%) patients had nodal lymphomas, and 183 (44%) had extranodal lymphomas. The commonest lymphoma was diffuse large cell (27%), followed by large cell immunoblastic (21%). The histopathologic pattern was follicular in 18% of the nodal lymphomas and in 5.3% of the extranodal forms. The most common site of extranodal lymphoma was the gastrointestinal tract (46.5%), followed by Waldeyer's ring (19%). Small intestinal lymphomas were three times more common than gastric lymphomas. Immunoproliferative small intestinal disease (IPSID) was diagnosed in 20 of 59 patients who had primary small intestinal lymphoma. Of the 34 patients who had Waldeyer's ring lymphoma, 7 had gastrointestinal involvement at some time during the course of the disease. Nodal lymphomas were associated with poor prognostic factors: 82% were diffuse; 77% had advanced disease at presentation; 77% had intermediate- or high-grade malignancy lymphoma; 40% had marrow involvement; and 46% had B symptoms. In children, the most common lymphoma was Burkitt's, and 80% of pediatric lymphomas were high-grade malignancy. In conclusion, this study delineates the special features of non-Hodgkin's lymphomas in the Middle East: The presence of IPSID; the high incidence of extranodal forms, in particular the intestinal ones; and the rarity of follicular lymphomas.
1974年1月至1983年12月期间，黎巴嫩贝鲁特的美国大学贝鲁特医疗中心共诊断出417例可评估的非霍奇金淋巴瘤患者。其中，179例（43%）为淋巴结淋巴瘤患者，183例（44%）为结外淋巴瘤患者。最常见的淋巴瘤是弥漫性大细胞淋巴瘤（27%），其次是大细胞免疫母细胞淋巴瘤（21%）。18%的淋巴结淋巴瘤和5.3%的结外淋巴瘤组织病理学模式为滤泡性。结外淋巴瘤最常见的部位是胃肠道（46.5%），其次是瓦尔代尔环（19%）。小肠淋巴瘤的发病率是胃淋巴瘤的三倍。59例原发性小肠淋巴瘤患者中有20例被诊断为免疫增殖性小肠疾病（IPSID）。在34例患有瓦尔代尔环淋巴瘤的患者中，7例在疾病过程中的某个时间出现了胃肠道受累。淋巴结淋巴瘤与不良预后因素相关：82%为弥漫性；77%在就诊时已处于晚期；77%为中或高级别恶性淋巴瘤；40%有骨髓受累；46%有B症状。在儿童中，最常见的淋巴瘤是伯基特淋巴瘤，80%的儿童淋巴瘤为高级别恶性。总之，本研究描述了中东地区非霍奇金淋巴瘤的特殊特征：IPSID的存在；结外形式尤其是肠道形式的高发病率；以及滤泡性淋巴瘤的罕见性。
