Tatsuta M, Iishi H, Ichii M, Noguchi S, Yamamura H, Taniguchi H
Cancer Res. 1986 Sep;46(9):4539-42.
The effects of the C-terminal tetrapeptide of gastrin, tetragastrin, on the colonic mucosa on Days 15 and 25 during intrarectal administration of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and its effects on the incidences of colonic tumors in experimental Wk 20 and 35 were investigated in Wistar rats. Administration of tetragastrin in depot form during instillation of MNNG resulted in significant decreases in the incidences of mucosal erosions, ulcerations, and atypical regenerative glandular hyperplasias in the colonic mucosa, most of these lesions being greater in the distal half of the colon. Administration of tetragastrin also significantly decreased the incidences and/or numbers of colonic tumors in Wk 20 and 35. The distribution of colonic tumors induced in Wk 20 and 35 corresponded well to those of erosions, ulcerations, and atypical regenerative glandular hyperplasias induced during the administration of MNNG. These findings suggest that the effect of tetragastrin in decreasing the incidences of erosions, ulcerations, and atypical regenerative glandular hyperplasias in the colonic mucosa during instillation of MNNG is related to its effect in reducing the development of colonic tumors.
在Wistar大鼠中，研究了胃泌素的C末端四肽（四肽胃泌素）在直肠内给予N-甲基-N'-硝基-N-亚硝基胍（MNNG）期间第15天和第25天对结肠黏膜的影响，以及其对实验第20周和第35周结肠肿瘤发生率的影响。在滴注MNNG期间以长效剂型给予四肽胃泌素，导致结肠黏膜中黏膜糜烂、溃疡和非典型再生性腺体增生的发生率显著降低，这些病变大多在结肠远端半部更为严重。给予四肽胃泌素还显著降低了第20周和第35周结肠肿瘤的发生率和/或数量。第20周和第35周诱导的结肠肿瘤分布与MNNG给药期间诱导的糜烂、溃疡和非典型再生性腺体增生的分布非常吻合。这些发现表明，四肽胃泌素在MNNG滴注期间降低结肠黏膜糜烂、溃疡和非典型再生性腺体增生发生率的作用与其在减少结肠肿瘤发生方面的作用有关。
