Pannese E, Procacci P, Ledda M, Arcidiacono G, Frattola D, Rigamonti L
Cell Tissue Res. 1986;245(1):1-8. doi: 10.1007/BF00218080.
The spatial relationship between microtubules and mitochondria was studied in myelinated axons of the ventral and dorsal spinal roots of the lizard Lacerta muralis by use of quantitative methods in single and serial sections. Microtubules mainly occurred in groups of 3 to 10. The mean density of microtubules was found to be significantly higher close to mitochondria than in the rest of the axoplasm. In single sections, 59-62% (according to the root region examined) of the microtubule groups were found to be 'associated' with mitochondria; this percentage rose to 74-76% in serial sections. The examination in serial sections of progressively longer segments of the same microtubule groups showed that the longer the segments of microtubule groups examined the higher was the percentage of microtubule groups 'associated' with mitochondria. The results obtained show that in the axons studied in the present research a non-accidental spatial association exists between microtubule groups and mitochondria. This evidence supports the suggestion that the microtubule groups play a role in the movement of mitochondria along the axon, even though it does not clarify the precise nature of this role.
利用单切片和连续切片的定量方法，对蜥蜴沙蜥脊髓腹侧和背侧神经根有髓轴突中微管与线粒体之间的空间关系进行了研究。微管主要以3至10个为一组出现。结果发现，靠近线粒体处微管的平均密度明显高于轴浆的其他部位。在单切片中，59%至62%（根据所检查的神经根区域）的微管组被发现与线粒体“相关”；在连续切片中，这一比例上升至74%至76%。对同一微管组逐渐延长的节段进行连续切片检查表明，所检查的微管组节段越长，与线粒体“相关”的微管组比例就越高。本研究所得结果表明，在本研究中所研究的轴突中，微管组与线粒体之间存在非偶然的空间关联。这一证据支持了微管组在沿轴突的线粒体移动中发挥作用的观点，尽管它并未阐明这一作用的确切性质。
