Abd El-Magid Wafaa Mohamed, Mohamed Raghda Alaa-Eldeen, Elsharkawy Reham Ezz-Eldawla
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University, Sohag, Egypt.
Dermatology, Venerology and Andrology Medical Administration, Sohag University, Sohag, Egypt.
J Cosmet Dermatol. 2023 Nov;22(11):2971-2981. doi: 10.1111/jocd.15805. Epub 2023 Jun 14.
Alopecia areata (AA) is a common disease characterized by hair loss with an autoimmune background. There are many lines of therapy, but no standard line for all cases. Consequently, treating severe forms of AA is challenging.
This study aimed to compare the efficacy and safety of the combination of diphenylcyclopropenone (DPCP) and platelet-rich plasma (PRP) with DPCP alone in treating patients with severe or refractory AA.
Our randomized clinical trial was conducted on patients with severe and recalcitrant AA. Group A included 13 patients who received only DPCP, while Group B included 11 patients who received both DPCP and PRP. After sensitization in both groups of patients, DPCP was applied to half the scalp weekly. In addition, PRP injection in all scalp was performed once a month in group B. The patients in both groups completed the study for six months.
The regrowth scale results were 53.85% and 54.5% for groups A and B, respectively. Although the response rate of group B was higher than that of group A, there is no statistically significant difference between the two groups.
From our clinical trial, it can be concluded that DPCP alone or combined with PRP is an effective and safe method for treating severe or recalcitrant AA.
斑秃（AA）是一种常见疾病，其特征为在自身免疫背景下出现脱发。治疗方法众多，但尚无适用于所有病例的标准治疗方案。因此，治疗重度斑秃具有挑战性。
本研究旨在比较二苯环丙烯酮（DPCP）与富血小板血浆（PRP）联合使用和单独使用DPCP治疗重度或难治性斑秃患者的疗效和安全性。
我们对重度和顽固性斑秃患者进行了随机临床试验。A组包括13例仅接受DPCP治疗的患者，B组包括11例接受DPCP和PRP联合治疗的患者。两组患者致敏后，每周将DPCP应用于一半头皮。此外，B组每月在整个头皮进行一次PRP注射。两组患者均完成为期6个月的研究。
A组和B组的毛发再生量表结果分别为53.85%和54.5%。虽然B组的有效率高于A组，但两组之间无统计学显著差异。
从我们的临床试验可以得出结论，单独使用DPCP或与PRP联合使用是治疗重度或顽固性斑秃的有效且安全的方法。
