在多个瘤牛群体中发现了与毛色深度相关的 ASIP 结构变异。

A structural variant at ASIP associated with the darkness of hair coat is found in multiple zebu cattle populations.

机构信息

Department of Production and Animal Health, School of Veterinary Medicine of Araçatuba, São Paulo State University (UNESP), Araçatuba, Brazil.

International Atomic Energy Agency (IAEA), Collaborating Centre on Animal Genomics and Bioinformatics, Araçatuba, Brazil.

出版信息

Anim Genet. 2023 Aug;54(4):544-548. doi: 10.1111/age.13333. Epub 2023 Jun 14.

DOI:10.1111/age.13333

PMID:37313778

Abstract

A structural variant (SV) in the agouti signaling protein gene (ASIP), namely ASIP-SV1, has been found to strongly correlate with the darkness of hair coat in specific regions of the body of bulls from the zebu (Bos indicus) Nellore breed. Here we visually analyzed the whole-genome sequence of zebu and taurine (Bos taurus) cattle to elucidate the extent of spread of ASIP-SV1 in different cattle populations. Of 216 sequences analyzed, 63 zebu (45.9%) and five taurine (6.3%) animals had at least one copy of ASIP-SV1. Four of the taurine animals presenting the SV were Romagnola cattle, a breed with history of zebu introgression. The remaining taurine animal was a Simmental, a breed frequently used in crossbreeding. These data provide evidence that ASIP-SV1 is commonly found in zebu populations, in addition to taurine animals with zebu admixture.

摘要

在泽布牛（印度野牛）的Nellore 品种的身体特定区域的毛色深度与刺鼠信号蛋白基因（ASIP）的结构变异（SV）强烈相关，该 SV 被命名为 ASIP-SV1。在此，我们对泽布牛和瘤牛（Bos taurus）牛的全基因组序列进行了直观分析，以阐明 ASIP-SV1 在不同牛群中的传播程度。在分析的 216 个序列中，63 头泽布牛（45.9%）和 5 头瘤牛（6.3%）动物至少有一个 ASIP-SV1 拷贝。呈现 SV 的 4 头瘤牛是 Romagnola 牛，该品种具有印度野牛基因渗入的历史。剩下的那头瘤牛是西门塔尔牛，该品种常用于杂交。这些数据表明，除了有印度野牛基因渗入的瘤牛动物之外，ASIP-SV1 也普遍存在于泽布牛群体中。