Ohzono K, Koyanagi S, Urabe Y, Harasawa Y, Tomoike H, Nakamura M
Circ Res. 1986 Jul;59(1):63-73. doi: 10.1161/01.res.59.1.63.
The evolution of myocardial infarction 24 hours after ligating both the right coronary artery and the obtuse marginal branch of the left circumflex coronary artery was examined in 33 anesthetized dogs. Postmortem coronary angiography and a tracer microsphere technique were used to determine risk areas and their collateral blood flows, respectively. The mean weight of the risk areas was 11.3 +/- 0.5 g (mean +/- SEM) in the right ventricle and 10.5 +/- 0.9 g in the left ventricle (NS). The weight of infarcted tissue was 5.7 +/- 0.7 g in the right ventricle and 5.2 +/- 0.9 g in the left ventricle (NS). In both ventricles, infarct weight was linearly related to risk area size, and the percent of risk area necrosis was inversely correlated with the extent of collateral flow at 24 hours of coronary ligation, defined as the mean myocardial blood flow inside the central risk area. Ratios of infarct to risk area between the subendocardial and subepicardial layers were 0.76 +/- 0.06 and 0.28 +/- 0.05 in the right and left ventricles, respectively (p less than 0.01, between ventricles, n = 31), which coincided well with subendocardial-to-subepicardial-flow ratios at 24 hours, ie, 0.86 +/- 0.04 in the right ventricle and 0.32 +/- 0.06 in the left ventricle (p less than 0.01). The regional distribution of myocardial infarction correlated well with flow distribution inside the risk area; the slope of these relations was similar between the subendocardium and subepicardium in the right ventricle, whereas in the left ventricle it was larger in the subendocardium than in the subepicardium. Thus, in the dog, the inherent change in the regional distribution of coronary collateral blood flow is an important modifier in the evolution of myocardial infarction, especially in the left ventricle.
在33只麻醉犬中，研究了结扎右冠状动脉和左旋支冠状动脉钝缘支24小时后心肌梗死的演变情况。分别采用死后冠状动脉造影和示踪微球技术来确定危险区域及其侧支血流。右心室危险区域的平均重量为11.3±0.5克（均值±标准误），左心室为10.5±0.9克（无显著性差异）。右心室梗死组织重量为5.7±0.7克，左心室为5.2±0.9克（无显著性差异）。在两个心室中，梗死重量与危险区域大小呈线性相关，并且在冠状动脉结扎24小时时，危险区域坏死百分比与侧支血流程度呈负相关，侧支血流程度定义为中央危险区域内的平均心肌血流。右心室和左心室内膜下与心外膜下梗死与危险区域的比值分别为0.76±0.06和0.28±0.05（心室间p<0.01，n = 31），这与24小时时内膜下与心外膜下血流比值非常吻合，即右心室为0.86±0.04，左心室为0.32±0.06（p<0.01）。心肌梗死的区域分布与危险区域内的血流分布密切相关；右心室心内膜下和心外膜下这些关系的斜率相似，而在左心室，心内膜下的斜率大于心外膜下。因此，在犬中，冠状动脉侧支血流区域分布的内在变化是心肌梗死演变的一个重要调节因素，尤其是在左心室。
