Gazi University Faculty of Medicine, Department of Pediatric Hematology, Ankara, Türkiye
Turk J Haematol. 2023 Aug 31;40(3):183-186. doi: 10.4274/tjh.galenos.2023.2023.0116. Epub 2023 Jun 14.
The purpose of this study was to identify risk factors and improve preventive strategies for febrile neutropenia (FEN) in children with leukemia who were receiving ciprofloxacin prophylaxis. The study included 100 children with leukemia [n=80 with acute lymphoblastic leukemia and n=20 with acute myeloblastic leukemia (AML)]. Patients were divided into two groups based on whether they had three or fewer FEN episodes (Group 1) or more than three FEN episodes (Group 2). Group 1 contained 63 (63%) of the 100 patients, while Group 2 contained 37 (37%). Older age (≥7 years), leukemia type, prolonged neutropenia (>10 days), and the presence of neutropenia and hypogammaglobulinemia at diagnosis were all risk factors for having more than three FEN episodes. Our findings suggest that, in addition to ciprofloxacin prophylaxis, identifying risk factors and improving preventive strategies could help reduce FEN episodes in children with leukemia.
本研究旨在确定接受环丙沙星预防的白血病患儿发生发热性中性粒细胞减少症（FEN）的危险因素，并改善预防策略。研究纳入了 100 例白血病患儿[n=80 例急性淋巴细胞白血病和 n=20 例急性髓细胞白血病（AML）]。根据 FEN 发作次数（发作次数≤3 次为组 1，发作次数>3 次为组 2）将患者分为两组。组 1 包括 100 例患者中的 63 例（63%），组 2 包括 37 例（37%）。年龄较大（≥7 岁）、白血病类型、中性粒细胞减少持续时间较长（>10 天）以及初诊时存在中性粒细胞减少和低丙种球蛋白血症是 FEN 发作次数>3 次的危险因素。我们的研究结果表明，除了环丙沙星预防外，识别危险因素并改善预防策略有助于减少白血病患儿的 FEN 发作次数。
