Eriguchi M, Mathé G
Drugs Exp Clin Res. 1986;12(1-3):51-6.
In an effort to establish a survival curve model which could help to evaluate adjuvant therapy, two equations were presented to approximate the various clinical curves. These curves usually show three different segments, describing high-risk, intermediate-risk and low-risk groups. The percentage of patients and the annual mortality in each risk group can be calculated from the coefficients of the equation. The present study analysed the survival curves of variously treated uterine cancer and stomach cancer after resection on the one hand, and of adjuvant therapy of breast cancer, malignant melanoma and acute lymphoid leukaemia on the other hand. This method of analysis should be useful for understanding and comparison of curves of phase III trials.
为了建立一个有助于评估辅助治疗的生存曲线模型，提出了两个方程来近似各种临床曲线。这些曲线通常显示三个不同的部分，分别描述高危、中危和低危组。每个风险组的患者百分比和年死亡率可以从方程的系数中计算出来。本研究一方面分析了各种治疗方式下子宫癌和胃癌切除术后的生存曲线，另一方面分析了乳腺癌、恶性黑色素瘤和急性淋巴细胞白血病辅助治疗后的生存曲线。这种分析方法对于理解和比较III期试验的曲线应该是有用的。
