Endocrinologia e Diabetologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.
Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy; Chirurgia Digestiva, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.
Mol Metab. 2023 Aug;74:101754. doi: 10.1016/j.molmet.2023.101754. Epub 2023 Jun 13.
Over the last decades, various approaches have been explored to restore sufficient β-cell mass in diabetic patients. Stem cells are certainly an attractive source of new β-cells, but an alternative option is to induce the endogenous regeneration of these cells.
Since the exocrine and endocrine pancreatic glands have a common origin and a continuous crosstalk unites the two, we believe that analyzing the mechanisms that induce pancreatic regeneration in different conditions could further advance our knowledge in the field. In this review, we summarize the latest evidence on physiological and pathological conditions associated with the regulation of pancreas regeneration and proliferation, as well as the complex and coordinated signaling cascade mediating cell growth.
Unraveling the mechanisms involved in intracellular signaling and regulation of pancreatic cell proliferation and regeneration may inspire future investigations to discover potential strategies to cure diabetes.
在过去的几十年中，人们探索了各种方法来恢复糖尿病患者足够的β细胞数量。干细胞无疑是新β细胞的一个有吸引力的来源，但另一种选择是诱导这些细胞的内源性再生。
由于外分泌和内分泌胰腺具有共同的起源，并且两者之间存在持续的串扰，因此我们认为分析不同条件下诱导胰腺再生的机制可以进一步促进我们在该领域的知识。在这篇综述中，我们总结了与调节胰腺再生和增殖相关的生理和病理条件以及介导细胞生长的复杂而协调的信号级联的最新证据。
阐明参与胰腺细胞增殖和再生的细胞内信号转导和调控的机制可能为未来发现治疗糖尿病的潜在策略提供启示。
Zotero 插件