Kiss J Z, Kanyicska B, Nagy G Y
Endocrinology. 1986 Aug;119(2):870-3. doi: 10.1210/endo-119-2-870.
The affect of paraventricular nucleus (PVN) lesions on PRL secretory response to suckling was studied in adult female rats. Basal levels of PRL were similar in the control and lesioned groups. Substantial decreases in PRL levels occurred after separation of pups from their mothers in the control as well as lesioned animals. When mothers and pups were reunited, the circulating PRL concentrations of the control groups rose immediately from basal values of 50-100 micrograms/liter to reach peaks of 450-550 micrograms/liter. PVN lesions significantly decreased the suckling-induced rise of PRL levels. Furthermore, PVN lesions abolished the high amplitude, episodic pattern of PRL release in continuously lactating rats. These findings are consistent with the view that PVN neurons produce PRL releasing factor(s), which is (are) required for normal secretory patterns of PRL in lactating rats.
在成年雌性大鼠中研究了室旁核（PVN）损伤对催乳素（PRL）分泌性哺乳反应的影响。对照组和损伤组的PRL基础水平相似。在对照组以及损伤动物中，幼崽与母亲分离后，PRL水平大幅下降。当母鼠与幼崽团聚时，对照组的循环PRL浓度立即从50 - 100微克/升的基础值上升至450 - 550微克/升的峰值。PVN损伤显著降低了哺乳诱导的PRL水平升高。此外，PVN损伤消除了持续泌乳大鼠中PRL释放的高幅度、间歇性模式。这些发现与以下观点一致，即PVN神经元产生PRL释放因子，这是泌乳大鼠中PRL正常分泌模式所必需的。
